Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.68 |
| ▸ | MEN1 | O00255 | 2/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.67 |
| ▸ | HTT | P42858 | 1/20 | 0.66 |
| ▸ | STAT3 | P40763 | 1/20 | 0.64 |
| ▸ | TSHR | P16473 | 1/20 | 0.62 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.61 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3380247 | 0.88 | POLB (0.68) | POLBMEN1KMT2AHTTALDH1A1 | |
| SCHEMBL789616 | 0.87 | KEAP1 (0.72) | POLBMEN1KMT2AHTTSTAT3 | |
| SCHEMBL7572319 | 0.87 | POLB (0.68) | POLBMEN1KMT2AHTTKEAP1 | |
| SCHEMBL2835167 | 0.86 | POLB (0.66) | POLBMEN1KMT2AHTTTSHR | |
| SCHEMBL2246137 | 0.86 | POLB (0.70) | POLBMEN1KMT2AHTTALDH1A1 | |
| SCHEMBL7586724 | 0.86 | NPC1 (0.68) | POLBMEN1KMT2AHTTTSHR | |
| SCHEMBL7570431 | 0.85 | POLB (0.61) | POLBMEN1KMT2AHTTALDH1A1 | |
| SCHEMBL7589375 | 0.84 | MEN1 (0.77) | MEN1KMT2ATSHRKEAP1NFE2L2 | |
| SCHEMBL7570459 | 0.83 | MEN1 (0.66) | POLBMEN1KMT2AHTTTSHR | |
| SCHEMBL1040233 | 0.83 | UQCRB (0.65) | POLBMEN1KMT2AHTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998029410-A1 | 1-(N'-(ARYLALKYLAMINOALKYL)) AMINOISOINDOLES; DOPAMINE RECEPTOR SUBTYPE SPECIFIC LIGANDS | NEUROGEN CORPORATION (US) | 1998-07-09 | — | — | WO | claimed |
| EP-1239852-A2 | BISSULFONAMIDE DERIVATIVES AS ENZYME INHIBITORS | Arrow Therapeutics Limited (GB) | 2002-09-18 | — | — | EP | disclosed |
| WO-2001028537-A2 | BISSULFONAMIDE DERIVATIVES AS ENZYME INHIBITORS | ARROW THERAPEUTICS LIMITED (GB) | 2001-04-26 | — | — | WO | disclosed |
| US-5728835-A | HYPOTENSIVE AGENTS; ANTIISCHEMIC AGENTS | TOA EIYO, LTD. (JP) | 1998-03-17 | — | — | US | disclosed |
| EP-0661266-A1 | Substituted cyclic amine compounds as 5HT2 antagonists | TOA EIYO LTD. (JP) | 1995-07-05 | — | — | EP | disclosed |