Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES1 | P23141 | 1/20 | 0.76 |
| ▸ | PGR | P06401 | 2/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.64 |
| ▸ | LMNA | P02545 | 2/20 | 0.64 |
| ▸ | MAPT | P10636 | 2/20 | 0.64 |
| ▸ | PKM | P14618 | 1/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.64 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.64 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.64 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.56 |
| ▸ | BRD1 | O95696 | 1/20 | 0.56 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.56 |
| ▸ | CCR2 | P41597 | 1/20 | 0.56 |
| ▸ | IDH1 | O75874 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | THRB | P10828 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15840715 | 0.89 | PPIA (0.70) | CES1PGRALDH1A1LMNAMAPT | |
| SCHEMBL17174220 | 0.87 | CES1 (0.67) | CES1PGRALDH1A1LMNAMAPT | |
| SCHEMBL2474197 | 0.87 | CES1 (1.00) | CES1PGRALDH1A1MAPTPKM | |
| SCHEMBL6554630 | 0.87 | CES1 (1.00) | CES1PGRALDH1A1MAPTPKM | |
| SCHEMBL11976998 | 0.86 | ALDH1A1 (0.64) | PGRALDH1A1LMNAMAPTPKM | |
| SCHEMBL13578719 | 0.86 | CES1 (0.65) | CES1PGRALDH1A1LMNAMAPT | |
| SCHEMBL95042 | 0.85 | MAPT (0.62) | CES1PGRALDH1A1LMNAMAPT | |
| SCHEMBL7176650 | 0.85 | LMNA (0.62) | CES1PGRALDH1A1LMNAMAPT | |
| SCHEMBL13995037 | 0.84 | PGR (0.69) | PGRALDH1A1LMNAMAPTPKM | |
| SCHEMBL965914 | 0.84 | CES1 (0.61) | CES1PGRALDH1A1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1239852-A2 | BISSULFONAMIDE DERIVATIVES AS ENZYME INHIBITORS | Arrow Therapeutics Limited (GB) | 2002-09-18 | — | — | EP | disclosed |
| WO-2001028537-A2 | BISSULFONAMIDE DERIVATIVES AS ENZYME INHIBITORS | ARROW THERAPEUTICS LIMITED (GB) | 2001-04-26 | — | — | WO | disclosed |