Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES2 | Q9H7Z7 | 5/20 | 0.60 |
| ▸ | CCR2 | P41597 | 3/20 | 0.51 |
| ▸ | ACLY | P53396 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | DDX3X | O00571 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5694587 | 0.87 | PTGES2 (0.69) | PTGES2CCR2ACLYKMT2AMEN1 | |
| SCHEMBL7572310 | 0.79 | ALDH1A1 (0.66) | KMT2AMEN1LMNAMAPTMAPK1 | |
| SCHEMBL7579231 | 0.79 | GAA (0.54) | KMT2AMEN1LMNAMAPTDDX3X | |
| SCHEMBL7570770 | 0.79 | GAA (0.61) | KMT2AMEN1LMNAMAPTDDX3X | |
| SCHEMBL7579848 | 0.78 | GAA (0.50) | CCR2KMT2AMEN1LMNAMAPT | |
| SCHEMBL11866689 | 0.77 | GAA (0.57) | PTGES2KMT2AMEN1LMNAMAPT | |
| SCHEMBL3773868 | 0.75 | PTGES2 (1.00) | PTGES2 | |
| SCHEMBL7578819 | 0.75 | MEN1 (0.63) | PTGES2CCR2ACLYKMT2AMEN1 | |
| SCHEMBL4191121 | 0.75 | PTGES2 (0.69) | PTGES2CCR2ACLYKMT2AMEN1 | |
| SCHEMBL7570701 | 0.74 | PTGES2 (0.60) | PTGES2ACLYKMT2AMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1239852-A2 | BISSULFONAMIDE DERIVATIVES AS ENZYME INHIBITORS | Arrow Therapeutics Limited (GB) | 2002-09-18 | — | — | EP | disclosed |
| WO-2001028537-A2 | BISSULFONAMIDE DERIVATIVES AS ENZYME INHIBITORS | ARROW THERAPEUTICS LIMITED (GB) | 2001-04-26 | — | — | WO | disclosed |