Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 5/20 | 0.50 |
| ▸ | MAPT | P10636 | 5/20 | 0.50 |
| ▸ | UQCRB | P14927 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.50 |
| ▸ | CCR2 | P41597 | 1/20 | 0.47 |
| ▸ | KEAP1 | Q14145 | 3/20 | 0.46 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.46 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | PGR | P06401 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7579231 | 0.83 | GAA (0.54) | GAAMAPTUQCRBHTTMEN1 | |
| SCHEMBL7572310 | 0.83 | ALDH1A1 (0.66) | GAAMAPTUQCRBHTTMEN1 | |
| SCHEMBL7570770 | 0.83 | GAA (0.61) | GAAMAPTUQCRBHTTMEN1 | |
| SCHEMBL7588944 | 0.82 | ALDH1A1 (0.56) | GAAMAPTMEN1KMT2ACCR2 | |
| SCHEMBL7570694 | 0.81 | FFAR4 (0.48) | GAAMAPTUQCRBHTTMEN1 | |
| SCHEMBL7570701 | 0.78 | PTGES2 (0.60) | GAAMAPTUQCRBHTTMEN1 | |
| SCHEMBL7572304 | 0.78 | PTGES2 (0.60) | GAAMAPTHTTMEN1KMT2A | |
| SCHEMBL23555160 | 0.77 | ALDH1A1 (0.71) | GAAMAPTMEN1KMT2AMAPK1 | |
| SCHEMBL7175064 | 0.77 | HSD17B2 (0.67) | MAPTUQCRBHTTKMT2AHSD17B2 | |
| SCHEMBL7572140 | 0.77 | RECQL (0.69) | GAAMAPTHTTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1239852-A2 | BISSULFONAMIDE DERIVATIVES AS ENZYME INHIBITORS | Arrow Therapeutics Limited (GB) | 2002-09-18 | — | — | EP | disclosed |
| WO-2001028537-A2 | BISSULFONAMIDE DERIVATIVES AS ENZYME INHIBITORS | ARROW THERAPEUTICS LIMITED (GB) | 2001-04-26 | — | — | WO | disclosed |