Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES2 | Q9H7Z7 | 2/20 | 0.60 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.59 |
| ▸ | UQCRB | P14927 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.56 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.55 |
| ▸ | PGAM1 | P18669 | 1/20 | 0.54 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.52 |
| ▸ | ACLY | P53396 | 1/20 | 0.49 |
| ▸ | KDM1A | O60341 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7578819 | 0.86 | MEN1 (0.63) | PTGES2HSD17B2MEN1KMT2ALMNA | |
| SCHEMBL7574025 | 0.82 | FFAR4 (0.56) | PTGES2HSD17B2UQCRBMEN1MAPT | |
| SCHEMBL7579231 | 0.82 | GAA (0.54) | HSD17B2UQCRBMEN1MAPTHTT | |
| SCHEMBL7572310 | 0.82 | ALDH1A1 (0.66) | HSD17B2UQCRBMEN1MAPTHTT | |
| SCHEMBL7570770 | 0.82 | GAA (0.61) | HSD17B2UQCRBMEN1MAPTHTT | |
| SCHEMBL7588697 | 0.81 | PTGES2 (0.74) | PTGES2HSD17B2UQCRBMEN1MAPT | |
| SCHEMBL7579848 | 0.78 | GAA (0.50) | HSD17B2UQCRBMEN1MAPTHTT | |
| SCHEMBL14403258 | 0.78 | PTGES2 (0.65) | PTGES2HSD17B2UQCRBMEN1MAPT | |
| SCHEMBL12406982 | 0.76 | PTGES2 (0.56) | PTGES2MEN1MAPTHTTKMT2A | |
| SCHEMBL7572596 | 0.75 | MEN1 (0.67) | PTGES2MEN1MAPTHTTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1239852-A2 | BISSULFONAMIDE DERIVATIVES AS ENZYME INHIBITORS | Arrow Therapeutics Limited (GB) | 2002-09-18 | — | — | EP | disclosed |
| WO-2001028537-A2 | BISSULFONAMIDE DERIVATIVES AS ENZYME INHIBITORS | ARROW THERAPEUTICS LIMITED (GB) | 2001-04-26 | — | — | WO | disclosed |