Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.56 |
| ▸ | PKM | P14618 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | GLA | P06280 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | RECQL | P46063 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | EDNRB | P24530 | 2/20 | 0.53 |
| ▸ | EDNRA | P25101 | 2/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.50 |
| ▸ | IDH1 | O75874 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7578851 | 0.88 | HSD11B1 (0.58) | HSD11B1MEN1KMT2AEDNRBEDNRA | |
| SCHEMBL3768958 | 0.86 | HSD11B1 (0.60) | ALDH1A1HSD11B1EDNRBEDNRAMAPT | |
| SCHEMBL95032 | 0.85 | HSD11B1 (0.59) | ALDH1A1HSD11B1PKMEDNRBEDNRA | |
| SCHEMBL7577401 | 0.81 | HSD11B1 (0.61) | HSD11B1EDNRBEDNRASLC40A1IDH1 | |
| SCHEMBL7594652 | 0.81 | SLC40A1 (0.53) | HSD11B1PKMEDNRBEDNRASLC40A1 | |
| SCHEMBL1471671 | 0.80 | EPAS1 (0.47) | ALDH1A1HSD11B1CYP3A4CYP2C9PKM | |
| SCHEMBL7591248 | 0.79 | HSD11B1 (0.63) | HSD11B1PKMEDNRBEDNRASLC40A1 | |
| SCHEMBL7591197 | 0.79 | PTGES2 (0.59) | HSD11B1PKMEDNRBEDNRASLC40A1 | |
| SCHEMBL4496737 | 0.78 | HSD11B1 (0.55) | ALDH1A1HSD11B1EDNRBEDNRAHTT | |
| SCHEMBL7594250 | 0.78 | SLC40A1 (0.66) | ALDH1A1HSD11B1PKMEDNRBEDNRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1239852-A2 | BISSULFONAMIDE DERIVATIVES AS ENZYME INHIBITORS | Arrow Therapeutics Limited (GB) | 2002-09-18 | — | — | EP | claimed |
| WO-2001028537-A2 | BISSULFONAMIDE DERIVATIVES AS ENZYME INHIBITORS | ARROW THERAPEUTICS LIMITED (GB) | 2001-04-26 | — | — | WO | claimed |
| EP-1239852-A2 | BISSULFONAMIDE DERIVATIVES AS ENZYME INHIBITORS | Arrow Therapeutics Limited (GB) | 2002-09-18 | — | — | EP | disclosed |
| WO-2001028537-A2 | BISSULFONAMIDE DERIVATIVES AS ENZYME INHIBITORS | ARROW THERAPEUTICS LIMITED (GB) | 2001-04-26 | — | — | WO | disclosed |