Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 3/20 | 0.61 |
| ▸ | SLC22A12 | Q96S37 | 8/20 | 0.54 |
| ▸ | EDNRB | P24530 | 2/20 | 0.50 |
| ▸ | EDNRA | P25101 | 2/20 | 0.50 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | KDM1A | O60341 | 1/20 | 0.46 |
| ▸ | IDH1 | O75874 | 1/20 | 0.46 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.46 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.46 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7578851 | 0.84 | HSD11B1 (0.58) | HSD11B1EDNRBEDNRASLC40A1IDH1 | |
| SCHEMBL7596336 | 0.83 | HSD11B1 (0.55) | HSD11B1SLC22A12EDNRBEDNRASLC40A1 | |
| SCHEMBL3768958 | 0.82 | HSD11B1 (0.60) | HSD11B1EDNRBEDNRASLC40A1CA1 | |
| SCHEMBL29561322 | 0.82 | MAPT (0.60) | HSD11B1KDM1A | |
| SCHEMBL95032 | 0.81 | HSD11B1 (0.59) | HSD11B1EDNRBEDNRASLC40A1 | |
| SCHEMBL7572722 | 0.81 | ALDH1A1 (0.56) | HSD11B1EDNRBEDNRASLC40A1IDH1 | |
| SCHEMBL2892307 | 0.80 | SLC22A12 (0.63) | SLC22A12CA1CA2KDM1AIDH1 | |
| SCHEMBL14433960 | 0.78 | HSD17B1 (0.56) | SLC22A12CA1CA2KDM1AIDH1 | |
| SCHEMBL7591248 | 0.76 | HSD11B1 (0.63) | HSD11B1EDNRBEDNRASLC40A1 | |
| SCHEMBL20354772 | 0.76 | DYRK1A (0.48) | HSD11B1SLC22A12CA1CA2TAS1R3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1239852-A2 | BISSULFONAMIDE DERIVATIVES AS ENZYME INHIBITORS | Arrow Therapeutics Limited (GB) | 2002-09-18 | — | — | EP | disclosed |
| WO-2001028537-A2 | BISSULFONAMIDE DERIVATIVES AS ENZYME INHIBITORS | ARROW THERAPEUTICS LIMITED (GB) | 2001-04-26 | — | — | WO | disclosed |