Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 5/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 5/20 | 0.39 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | CCNC | P24863 | 1/20 | 0.35 |
| ▸ | CDK8 | P49336 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23934132 | 0.80 | CHRNB2 (0.44) | CHRNB2CHRNA4LMNATDP1KMT2A | |
| SCHEMBL30181676 | 0.72 | LMNA (0.47) | CHRNB2CHRNA4LMNATDP1CYP3A4 | |
| SCHEMBL2303193 | 0.71 | NPC1 (0.51) | CHRNB2CHRNA4GRM2LMNATDP1 | |
| SCHEMBL29497468 | 0.71 | NPC1 (0.51) | CHRNB2CHRNA4GRM2LMNATDP1 | |
| SCHEMBL2301119 | 0.71 | LMNA (0.50) | CHRNB2CHRNA4LMNATDP1CYP3A4 | |
| SCHEMBL7099252 | 0.71 | CHRNB2 (0.45) | CHRNB2CHRNA4LMNATDP1CYP3A4 | |
| SCHEMBL8066263 | 0.71 | LTA4H (0.34) | CHRNB2CHRNA4 | |
| SCHEMBL23934127 | 0.71 | CNR1 (0.45) | CHRNB2CHRNA4LMNATDP1KMT2A | |
| SCHEMBL26146529 | 0.69 | LMNA (0.44) | CHRNB2CHRNA4LMNATDP1KMT2A | |
| SCHEMBL7246559 | 0.69 | CHRNB2 (0.42) | CHRNB2CHRNA4LMNATDP1CCNC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1171127-A2 | PHARMACEUTICAL COMPOSITIONS CONTAINING PYRIDINE OR PYRIMIDINE DERIVATIVES FOR INHIBITION OF CYTOKINE PRODUCTION AND SECRETION | Targacept, Inc. (US) | 2002-01-16 | — | — | EP | disclosed |
| WO-2000062767-A2 | PHARMACEUTICAL COMPOSITIONS CONTAINING PYRIDINE OR PYRIMIDINE DERIVATES FOR INHIBITION OF CYTOKINE PRODUCTION AND SECRETION | TARGACEPT, INC. (US) | 2000-10-26 | — | — | WO | disclosed |