SCHEMBL8066263

SCHEMBL8066263

CCC(N)(Oc1ccccc1)C(F)(F)F

nearest known ligand 0.41

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
LTA4H P09960 2/20 0.34
KIF11 P52732 2/20 0.34
GRIN2B Q13224 1/20 0.33
CA4 P22748 1/20 0.33
TAAR1 Q96RJ0 2/20 0.32
SLC6A2 P23975 1/20 0.32
CCR6 P51684 1/20 0.32
SLC7A5 Q01650 2/20 0.32
MAPT P10636 1/20 0.32
HTT P42858 1/20 0.32
CHRNB2 P17787 1/20 0.32
CHRNB4 P30926 1/20 0.32
CHRNA3 P32297 1/20 0.32
CHRNA7 P36544 1/20 0.32
CHRNA4 P43681 1/20 0.32
KCNA3 P22001 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9910049 0.75 LTA4H (0.39) LTA4HCA4SLC6A2CCR6CHRNB2
SCHEMBL5323612 0.75 LTA4H (0.39) LTA4HCA4TAAR1SLC6A2CHRNB2
SCHEMBL5286690 0.74 TAAR1 (0.40) LTA4HCA4TAAR1SLC6A2CHRNB2
SCHEMBL10498164 0.73 MLYCD (0.39) LTA4HKIF11GRIN2BCA4TAAR1
SCHEMBL183720 0.73 LTA4H (0.40) LTA4HCA4TAAR1SLC6A2CHRNB2
SCHEMBL5674225 0.72 LTA4H (0.36) LTA4HCA4TAAR1SLC6A2CCR6
SCHEMBL8761205 0.72 CCR6 (0.37) LTA4HKIF11CA4CCR6
SCHEMBL7574405 0.71 CHRNB2 (0.39) CHRNB2CHRNA4
SCHEMBL2763256 0.71 KCNN4 (0.39) LTA4HKIF11CA4TAAR1
Methylamine SCHEMBL27709879 0.70 KIF11 (0.47) KIF11GRIN2BCA4SLC6A2CCR6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1003717-A1 PREPARATION AND USES OF HYDROCARBYLNITRONES ALBEMARLE CORPORATION (US) 2000-05-31 EP disclosed
WO-1999006362-A1 PREPARATION AND USES OF HYDROCARBYLNITRONES ALBEMARLE CORPORATION (US) 1999-02-11 WO disclosed