Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.33 |
| ▸ | DRD4 | P21917 | 8/20 | 0.32 |
| ▸ | DRD2 | P14416 | 5/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7864156 | 0.86 | DRD4 (0.39) | LMNAPOLBMEN1ALDH1A1KMT2A | |
| SCHEMBL7778596 | 0.75 | GRIN2B (0.38) | LMNAPOLBCYP1A2CYP2C19MEN1 | |
| SCHEMBL7861405 | 0.75 | PPARG (0.39) | LMNAPOLBCYP1A2CYP2D6CYP2C9 | |
| SCHEMBL6811236 | 0.66 | TRPA1 (0.49) | LMNAMEN1KMT2ADRD4DRD2 | |
| SCHEMBL27548769 | 0.65 | GSK3B (0.49) | CYP1A2GSK3BGAA | |
| SCHEMBL28113822 | 0.64 | ALDH1A1 (0.57) | LMNACYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL7569694 | 0.63 | MAOB (0.38) | LMNAPOLBMEN1ALDH1A1KMT2A | |
| SCHEMBL7844834 | 0.63 | GCGR (0.33) | LMNAALDH1A1DRD4DRD2MAPT | |
| SCHEMBL27469352 | 0.62 | DRD4 (0.49) | CYP1A2CYP2D6CYP2C9CYP2C19MEN1 | |
| SCHEMBL7575131 | 0.62 | AKR1B1 (0.36) | MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1144399-A3 | HETEROCYCLIC CARBOXAMIDE-CONTAINING THIOUREA INHIBITORS OF HERPES VIRUSES CONTAINING A SUBSTITUTED PHENYLENEDIAMINE GROUP | Wyeth (US) | 2002-09-11 | — | — | EP | disclosed |
| EP-1144399-A2 | HETEROCYCLIC CARBOXAMIDE-CONTAINING THIOUREA INHIBITORS OF HERPES VIRUSES CONTAINING A SUBSTITUTED PHENYLENEDIAMINE GROUP | AMERICAN HOME PRODUCTS CORPORATION (US) | 2001-10-17 | — | — | EP | disclosed |
| WO-2000034261-A2 | HETEROCYCLIC CARBOXAMIDE-CONTAINING THIOUREA INHIBITORS OF HERPES VIRUSES CONTAINING A SUBSTITUTED PHENYLENEDIAMINE GROUP | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-06-15 | — | — | WO | disclosed |