Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | PLK1 | P53350 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27989848 | 0.79 | GAA (0.36) | ALDH1A1HDAC8HDAC6HDAC2GAA | |
| SCHEMBL10388317 | 0.79 | THRB (0.31) | ALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7585606 | 0.78 | ALDH1A1 (0.39) | ALDH1A1HDAC8HDAC6HDAC2KMT2A | |
| SCHEMBL18706241 | 0.78 | GAA (0.52) | ALDH1A1HDAC8HDAC6HDAC2KMT2A | |
| SCHEMBL8672377 | 0.78 | ALDH1A1 (0.38) | ALDH1A1HDAC8HDAC6HDAC2KMT2A | |
| SCHEMBL1180898 | 0.76 | PRNP (0.34) | ALDH1A1KMT2AGAANPC1RAB9A | |
| SCHEMBL4287351 | 0.74 | GAA (0.41) | ALDH1A1HDAC8HDAC6HDAC2GAA | |
| SCHEMBL7574535 | 0.74 | F10 (0.45) | ALDH1A1HDAC8KMT2AGAANPC1 | |
| SCHEMBL7578861 | 0.74 | HPGD (0.51) | ALDH1A1HDAC8HDAC6HDAC2KMT2A | |
| SCHEMBL7582847 | 0.70 | CREBBP (0.41) | HDAC8HDAC6HDAC2KMT2ACREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0882730-B1 | PHOSPHONIC ACID DIESTER DERIVATIVES | OTSUKA PHARMA CO LTD (JP) | 2002-10-02 | — | — | EP | disclosed |
| US-5985858-A | TREATING AND PREVENTING HYPERLIPIDEMIA, DIABETES AND CATARACT, OR AS AN ANTITUMOR AGENT | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1999-11-16 | — | — | US | disclosed |
| EP-0882730-A1 | PHOSPHONIC ACID DIESTER DERIVATIVES | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1998-12-09 | — | — | EP | disclosed |