Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | SLC10A2 | Q12908 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | EDNRB | P24530 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | GNRHR | P30968 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7571920 | 0.92 | HDAC6 (0.41) | PTGDR2HDAC6MAPTTP53ALDH1A1 | |
| SCHEMBL8923924 | 0.91 | HDAC6 (0.40) | PTGDR2HDAC6MAPTTP53ALDH1A1 | |
| SCHEMBL7512664 | 0.85 | SLC10A2 (0.43) | MAPTTP53ALDH1A1USP2NPSR1 | |
| SCHEMBL7511306 | 0.83 | MAPT (0.38) | PTGDR2HDAC6MAPTTP53ALDH1A1 | |
| SCHEMBL7572056 | 0.81 | PTGDR2 (0.41) | PTGDR2ALDH1A1EDNRBSMN1; SMN2 | |
| SCHEMBL8915668 | 0.79 | HDAC6 (0.37) | PTGDR2HDAC6MAPTTP53ALDH1A1 | |
| SCHEMBL7511671 | 0.77 | HDAC6 (0.39) | PTGDR2HDAC6MAPTALDH1A1USP2 | |
| SCHEMBL7506489 | 0.77 | PTGDR2 (0.35) | PTGDR2HDAC6MAPTTP53ALDH1A1 | |
| SCHEMBL7508121 | 0.75 | GAA (0.49) | MAPTALDH1A1NPSR1EDNRBHPGD | |
| SCHEMBL7516884 | 0.72 | FEN1 (0.37) | HDAC6MAPTTP53ALDH1A1USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5654309-A | KIDNEY, CARDIOVASCULAR AND RESPIRATORY SYSTEM DISORDERS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-08-05 | — | — | US | claimed |
| EP-0608565-B1 | Pyridopyrimidine derivatives, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2002-03-13 | — | — | EP | disclosed |
| US-5654309-A | KIDNEY, CARDIOVASCULAR AND RESPIRATORY SYSTEM DISORDERS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-08-05 | — | — | US | disclosed |