Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FEN1 | P39748 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | EDNRB | P24530 | 6/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | GNRHR | P30968 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7511671 | 0.84 | HDAC6 (0.39) | FEN1MEN1KMT2APKMEDNRB | |
| SCHEMBL7571920 | 0.79 | HDAC6 (0.41) | MEN1KMT2APKMEDNRBMAPT | |
| SCHEMBL8915668 | 0.77 | HDAC6 (0.37) | MEN1KMT2APKMMAPTTP53 | |
| SCHEMBL8914836 | 0.76 | PTGDR2 (0.38) | MEN1KMT2AEDNRB | |
| SCHEMBL7512664 | 0.76 | SLC10A2 (0.43) | EDNRBMAPTTP53GNRHRMAPK1 | |
| SCHEMBL7506489 | 0.75 | PTGDR2 (0.35) | MEN1KMT2AMAPTTP53GNRHR | |
| SCHEMBL8923924 | 0.73 | HDAC6 (0.40) | MEN1KMT2APKMMAPTTP53 | |
| SCHEMBL7574883 | 0.72 | PTGDR2 (0.40) | MEN1KMT2APKMEDNRBMAPT | |
| SCHEMBL7508121 | 0.67 | GAA (0.49) | MEN1KMT2AEDNRBMAPTGNRHR | |
| SCHEMBL7842798 | 0.63 | MAPK8 (0.46) | FEN1MEN1KMT2APKMEDNRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0608565-B1 | Pyridopyrimidine derivatives, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2002-03-13 | — | — | EP | disclosed |
| US-5654309-A | KIDNEY, CARDIOVASCULAR AND RESPIRATORY SYSTEM DISORDERS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-08-05 | — | — | US | disclosed |