Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 4/20 | 0.41 |
| ▸ | EDNRB | P24530 | 1/20 | 0.36 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.33 |
| ▸ | FEN1 | P39748 | 1/20 | 0.33 |
| ▸ | AKR1B10 | O60218 | 8/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
| ▸ | CMA1 | P23946 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.31 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7571920 | 0.88 | HDAC6 (0.41) | PTGDR2EDNRBALDH1A1 | |
| SCHEMBL8923666 | 0.87 | EDNRB (0.34) | PTGDR2EDNRBKDM5BFEN1CMA1 | |
| SCHEMBL8923924 | 0.83 | HDAC6 (0.40) | PTGDR2ALDH1A1 | |
| SCHEMBL7574883 | 0.81 | PTGDR2 (0.40) | PTGDR2EDNRBALDH1A1SMN1; SMN2 | |
| SCHEMBL7511671 | 0.74 | HDAC6 (0.39) | PTGDR2EDNRBFEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL8914836 | 0.70 | PTGDR2 (0.38) | PTGDR2EDNRBTSHR | |
| SCHEMBL8915668 | 0.66 | HDAC6 (0.37) | PTGDR2ALDH1A1SMN1; SMN2 | |
| SCHEMBL7512664 | 0.64 | SLC10A2 (0.43) | EDNRBALDH1A1SMN1; SMN2 | |
| SCHEMBL7506489 | 0.64 | PTGDR2 (0.35) | PTGDR2ALDH1A1SMN1; SMN2 | |
| SCHEMBL7594594 | 0.64 | KMT2A (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0608565-B1 | Pyridopyrimidine derivatives, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2002-03-13 | — | — | EP | claimed |
| US-5654309-A | KIDNEY, CARDIOVASCULAR AND RESPIRATORY SYSTEM DISORDERS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-08-05 | — | — | US | claimed |
| EP-0608565-A1 | Pyridopyrimidine derivatives, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1994-08-03 | — | — | EP | claimed |
| EP-0608565-B1 | Pyridopyrimidine derivatives, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2002-03-13 | — | — | EP | disclosed |
| US-5654309-A | KIDNEY, CARDIOVASCULAR AND RESPIRATORY SYSTEM DISORDERS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-08-05 | — | — | US | disclosed |
| EP-0608565-A1 | Pyridopyrimidine derivatives, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1994-08-03 | — | — | EP | disclosed |