Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | GNRHR | P30968 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | AKT1 | P31749 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7571920 | 0.94 | HDAC6 (0.41) | HDAC6PTGDR2MAPTTP53ALDH1A1 | |
| SCHEMBL7574883 | 0.91 | PTGDR2 (0.40) | HDAC6PTGDR2MAPTTP53ALDH1A1 | |
| SCHEMBL7572056 | 0.83 | PTGDR2 (0.41) | PTGDR2ALDH1A1 | |
| SCHEMBL7511671 | 0.79 | HDAC6 (0.39) | HDAC6PTGDR2MAPTALDH1A1NPSR1 | |
| SCHEMBL8915668 | 0.75 | HDAC6 (0.37) | HDAC6PTGDR2MAPTTP53ALDH1A1 | |
| SCHEMBL7512664 | 0.75 | SLC10A2 (0.43) | MAPTTP53ALDH1A1NPSR1USP2 | |
| SCHEMBL7516884 | 0.73 | FEN1 (0.37) | HDAC6MAPTTP53ALDH1A1NPSR1 | |
| SCHEMBL7506489 | 0.73 | PTGDR2 (0.35) | HDAC6PTGDR2MAPTTP53ALDH1A1 | |
| SCHEMBL8914836 | 0.71 | PTGDR2 (0.38) | PTGDR2KMT2AMEN1 | |
| SCHEMBL8923666 | 0.70 | EDNRB (0.34) | PTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5654309-A | KIDNEY, CARDIOVASCULAR AND RESPIRATORY SYSTEM DISORDERS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-08-05 | — | — | US | disclosed |