Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VCAM1 | P19320 | 4/20 | 0.59 |
| ▸ | MERTK | Q12866 | 2/20 | 0.40 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.37 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.37 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.37 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.37 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | CCR6 | P51684 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6549707 | 0.81 | VCAM1 (0.47) | VCAM1MERTKMAPTMEN1KMT2A | |
| SCHEMBL25258938 | 0.77 | VCAM1 (0.70) | VCAM1MERTKGRIN2DGRIN3BGRIN1 | |
| SCHEMBL645653 | 0.76 | VCAM1 (1.00) | VCAM1MERTKGRIN2DGRIN3BGRIN1 | |
| SCHEMBL7569366 | 0.75 | L3MBTL1 (0.44) | VCAM1MAPTMEN1KMT2AGAA | |
| SCHEMBL22922929 | 0.74 | VCAM1 (0.52) | VCAM1MERTKGRIN2DGRIN3BGRIN1 | |
| SCHEMBL29459431 | 0.74 | VCAM1 (0.52) | VCAM1MERTKGRIN2DGRIN3BGRIN1 | |
| SCHEMBL7566540 | 0.74 | PIN1 (0.41) | VCAM1MERTKMAPTMEN1KMT2A | |
| SCHEMBL7567974 | 0.73 | MAPT (0.43) | VCAM1MAPTMEN1KMT2AHPGD | |
| SCHEMBL12006023 | 0.73 | RAB9A (0.46) | MAPTMEN1KMT2AGAATSHR | |
| SCHEMBL28338065 | 0.73 | CYP3A4 (0.40) | MAPTMEN1KMT2AGAATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1136192-C | Aryl and heteroaryl sulfonamide derivatives, their preparation and their use as endothelin antagonists | - | 2004-01-28 | — | — | CN | disclosed |
| EP-0799206-B1 | ARYL- AND HETARYL-SULFONAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS ENDOTHELIN ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2002-09-11 | — | — | EP | disclosed |
| US-6133442-A | FOR THE TREATMENT OF DISORDERS WHICH ARE ASSOCIATED WITH ENDOTHELIN ACTIVITIES, ESPECIALLY CIRCULATORY DISORDERS SUCH AS HYPERTENSION, ISCHAEMIA, VASOSPASMS AND ANGINA PECTORIS | HOFFMANN-LA ROCHE INC. (US) | 2000-10-17 | — | — | US | disclosed |
| US-5962682-A | Aryl- and hetaryl-sulfonamide derivatives, their preparation and their use as endothelin antagonists | HOFFMANN-LA ROCHE INC. (US) | 1999-10-05 | — | — | US | disclosed |
| CN-1170405-A | Aryl and heteroaryl sulfonamide derivatives, their preparation and their use as endothelin antagonists | HOFFMANN LA ROCHE (CH) | 1998-01-14 | — | — | CN | disclosed |
| EP-0799206-A1 | ARYL- AND HETARYL-SULFONAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS ENDOTHELIN ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 1997-10-08 | — | — | EP | disclosed |
| WO-1996019455-A1 | ARYL- AND HETARYL-SULFONAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS ENDOTHELIN ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 1996-06-27 | — | — | WO | disclosed |