Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | PPARA | Q07869 | 8/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.42 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.41 |
| ▸ | GLB1 | P16278 | 1/20 | 0.41 |
| ▸ | CTRC | Q99895 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7496577 | 0.89 | PDK1 (0.40) | SMN1; SMN2NPSR1PPARAMAOAMAOB | |
| SCHEMBL7493616 | 0.86 | ALOX5 (0.41) | SMN1; SMN2NPSR1PPARAMAOAMAOB | |
| SCHEMBL7506690 | 0.81 | SMN1; SMN2 (0.51) | SMN1; SMN2NPSR1PPARAALOX5GLB1 | |
| SCHEMBL12585014 | 0.79 | SMN1; SMN2 (0.49) | SMN1; SMN2NPSR1PPARAMAOAMAOB | |
| SCHEMBL12584989 | 0.77 | SMN1; SMN2 (0.52) | SMN1; SMN2NPSR1PPARAMAOAMAOB | |
| SCHEMBL2029836 | 0.75 | PPARA (0.47) | SMN1; SMN2NPSR1PPARAMAOAMAOB | |
| SCHEMBL12585038 | 0.75 | SMN1; SMN2 (0.50) | SMN1; SMN2NPSR1PPARAMAOAMAOB | |
| SCHEMBL5713090 | 0.75 | PPARA (0.44) | SMN1; SMN2NPSR1PPARAMAOAMAOB | |
| SCHEMBL2033025 | 0.73 | SMN1; SMN2 (0.47) | SMN1; SMN2NPSR1PPARAMAOAMAOB | |
| SCHEMBL12584984 | 0.70 | PDK1 (0.41) | SMN1; SMN2NPSR1PPARAMAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1192137-A1 | COMPOUNDS FOR THE MODULATION OF PPAR$g(g) ACTIVITY | Tularik Inc. (US) | 2002-04-03 | — | — | EP | disclosed |
| WO-2001000579-A1 | COMPOUNDS FOR THE MODULATION OF PPARη ACTIVITY | TULARIK INC. (US) | 2001-01-04 | — | — | WO | disclosed |