Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 7/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.39 |
| ▸ | HTT | P42858 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | PPARA | Q07869 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 2/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | MMP2 | P08253 | 1/20 | 0.34 |
| ▸ | MMP9 | P14780 | 1/20 | 0.34 |
| ▸ | MMP8 | P22894 | 1/20 | 0.34 |
| ▸ | MMP13 | P45452 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7575462 | 0.89 | SMN1; SMN2 (0.47) | PDK1MAPTSMN1; SMN2KMT2AHTT | |
| SCHEMBL7493616 | 0.84 | ALOX5 (0.41) | PDK1MAPTSMN1; SMN2KMT2AHTT | |
| SCHEMBL12584984 | 0.81 | PDK1 (0.41) | PDK1MAPTSMN1; SMN2KMT2AHTT | |
| SCHEMBL2031059 | 0.77 | MEN1 (0.41) | PDK1MAPTSMN1; SMN2KMT2AHTT | |
| SCHEMBL12584969 | 0.77 | PDK1 (0.45) | PDK1MAPTSMN1; SMN2KMT2AHTT | |
| SCHEMBL5713084 | 0.76 | MAPT (0.40) | PDK1MAPTSMN1; SMN2KMT2AHTT | |
| SCHEMBL12585014 | 0.72 | SMN1; SMN2 (0.49) | PDK1MAPTSMN1; SMN2KMT2AHTT | |
| SCHEMBL2001086 | 0.70 | RIPK1 (0.39) | MAPTSMN1; SMN2KMT2AHTTMEN1 | |
| SCHEMBL12584989 | 0.70 | SMN1; SMN2 (0.52) | PDK1MAPTSMN1; SMN2KMT2AHTT | |
| SCHEMBL7506690 | 0.70 | SMN1; SMN2 (0.51) | SMN1; SMN2NPSR1PPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1192137-A1 | COMPOUNDS FOR THE MODULATION OF PPAR$g(g) ACTIVITY | Tularik Inc. (US) | 2002-04-03 | — | — | EP | disclosed |
| WO-2001000579-A1 | COMPOUNDS FOR THE MODULATION OF PPARη ACTIVITY | TULARIK INC. (US) | 2001-01-04 | — | — | WO | disclosed |