Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VNN1 | O95497 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | DDR1 | Q08345 | 4/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.32 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7575921 | 0.78 | KMT2A (0.42) | NPSR1KMT2AMEN1GAAKDM4E | |
| SCHEMBL7846221 | 0.77 | KMT2A (0.43) | NPSR1KMT2AMEN1GAAPOLB | |
| SCHEMBL7866288 | 0.75 | EPHX2 (0.38) | KMT2AGAAMAPTPOLB | |
| SCHEMBL7861383 | 0.74 | HIF1A (0.39) | KMT2AMEN1KDM4EMAPTHIF1A | |
| SCHEMBL6819739 | 0.74 | KMT2A (0.57) | NPSR1KMT2AMEN1GAAMAPT | |
| SCHEMBL29778306 | 0.74 | KMT2A (0.57) | NPSR1KMT2AMEN1GAAMAPT | |
| SCHEMBL6819302 | 0.74 | KMT2A (0.57) | NPSR1KMT2AMEN1GAAMAPT | |
| SCHEMBL7569653 | 0.74 | IDO1 (0.50) | KMT2AMEN1KDM4EPOLB | |
| SCHEMBL7868617 | 0.73 | S1PR1 (0.34) | KMT2AMEN1S1PR1S1PR3 | |
| SCHEMBL7868713 | 0.72 | MAOB (0.46) | NPSR1KMT2AMEN1KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1144399-A3 | HETEROCYCLIC CARBOXAMIDE-CONTAINING THIOUREA INHIBITORS OF HERPES VIRUSES CONTAINING A SUBSTITUTED PHENYLENEDIAMINE GROUP | Wyeth (US) | 2002-09-11 | — | — | EP | disclosed |
| EP-1144399-A2 | HETEROCYCLIC CARBOXAMIDE-CONTAINING THIOUREA INHIBITORS OF HERPES VIRUSES CONTAINING A SUBSTITUTED PHENYLENEDIAMINE GROUP | AMERICAN HOME PRODUCTS CORPORATION (US) | 2001-10-17 | — | — | EP | disclosed |
| WO-2000034261-A2 | HETEROCYCLIC CARBOXAMIDE-CONTAINING THIOUREA INHIBITORS OF HERPES VIRUSES CONTAINING A SUBSTITUTED PHENYLENEDIAMINE GROUP | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-06-15 | — | — | WO | disclosed |