Propaquizafop

Propaquizafop

SCHEMBL7576944

CC(C)=NOCCOC(=O)[C@@H](C)Oc1ccc(Oc2cnc3cc(Cl)ccc3n2)cc1.CC(C)Oc1cc(-n2nc(C(C)(C)C)oc2=O)c(Cl)cc1Cl

nearest known ligand 0.49

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PPOX P50336 13/20 0.49
MEN1 O00255 3/20 0.49
KMT2A Q03164 3/20 0.49
TDP1 Q9NUW8 2/20 0.49
NR1I2 O75469 1/20 0.49
HPGD P15428 3/20 0.42
ALDH1A1 P00352 2/20 0.42
LMNA P02545 2/20 0.42
TP53 P04637 1/20 0.42
CYP1A2 P05177 1/20 0.42
CYP3A4 P08684 1/20 0.42
ALOX15 P16050 1/20 0.42
NFKB1 P19838 1/20 0.42
HIF1A Q16665 1/20 0.42
GMNN O75496 1/20 0.42
MAPT P10636 1/20 0.42
APEX1 P27695 1/20 0.42
PMP22 Q01453 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
NPSR1 Q6W5P4 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Propaquizafop SCHEMBL7584901 0.93 PPOX (0.40) PPOXMEN1KMT2ATDP1NR1I2
Quizalofop SCHEMBL7580363 0.87 PPOX (0.57) PPOXMEN1KMT2ATDP1NR1I2
Propaquizafop SCHEMBL9136963 0.81 MAPT (0.61) MEN1KMT2ATDP1HPGDALDH1A1
Propaquizafop SCHEMBL54333 0.81 MAPT (0.61) MEN1KMT2ATDP1HPGDALDH1A1
Propaquizafop SCHEMBL43925 0.81 MAPT (0.61) MEN1KMT2ATDP1HPGDALDH1A1
Quizalofop SCHEMBL7581424 0.80 PPOX (0.45) PPOXMEN1KMT2ATDP1NR1I2
Propaquizafop SCHEMBL2317541 0.79 ALDH1A1 (0.57) MEN1KMT2ATDP1HPGDALDH1A1
Propaquizafop SCHEMBL8540160 0.78 MAPT (0.58) MEN1KMT2ATDP1HPGDALDH1A1
SCHEMBL10959202 0.78 MAPT (0.63) MEN1KMT2ATDP1HPGDALDH1A1
Propaquizafop SCHEMBL28841958 0.77 MAPT (0.56) MEN1KMT2ATDP1HPGDALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20020004457-A1 Herbicidal composition SYNGENTA PARTICIPATIONS AG (CH) 2002-01-10 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020004457-A1 Herbicidal composition PPOX, ALAD, DDT PPOX 1/4885MEN1 4274/4885KMT2A 2099/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.