Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | PKM | P14618 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | THRB | P10828 | 1/20 | 0.56 |
| ▸ | BRD4 | O60885 | 2/20 | 0.54 |
| ▸ | BRD1 | O95696 | 4/20 | 0.54 |
| ▸ | BRPF1 | P55201 | 4/20 | 0.54 |
| ▸ | BRPF3 | Q9ULD4 | 3/20 | 0.54 |
| ▸ | PGR | P06401 | 1/20 | 0.54 |
| ▸ | AR | P10275 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.51 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.51 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.51 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6555449 | 0.83 | KDM1A (0.68) | KDM1AALDH1A1LMNAMAPTCYP19A1 | |
| SCHEMBL7572500 | 0.83 | CES1 (0.73) | KDM1AALDH1A1LMNAMAPTCYP19A1 | |
| SCHEMBL27888183 | 0.83 | CA1 (0.65) | KDM1AALDH1A1MAPTCYP19A1TP53 | |
| SCHEMBL6554559 | 0.83 | CES1 (0.73) | KDM1AALDH1A1LMNAMAPTCYP19A1 | |
| SCHEMBL7590378 | 0.81 | CCR2 (0.48) | KDM1AMAPTSMN1; SMN2TP53BRD1 | |
| SCHEMBL11976998 | 0.81 | ALDH1A1 (0.64) | ALDH1A1LMNAMAPTPKMSMN1; SMN2 | |
| SCHEMBL7572277 | 0.81 | CES1 (0.76) | ALDH1A1LMNAMAPTPKMSMN1; SMN2 | |
| SCHEMBL7281538 | 0.80 | KDM1A (0.68) | KDM1ALMNAMAPTSMN1; SMN2CYP19A1 | |
| SCHEMBL96241 | 0.80 | KDM1A (0.64) | KDM1AALDH1A1MAPTPKMCYP19A1 | |
| SCHEMBL95042 | 0.80 | MAPT (0.62) | ALDH1A1LMNAMAPTPKMSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1239852-A2 | BISSULFONAMIDE DERIVATIVES AS ENZYME INHIBITORS | Arrow Therapeutics Limited (GB) | 2002-09-18 | — | — | EP | disclosed |
| WO-2001028537-A2 | BISSULFONAMIDE DERIVATIVES AS ENZYME INHIBITORS | ARROW THERAPEUTICS LIMITED (GB) | 2001-04-26 | — | — | WO | disclosed |