Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.60 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.54 |
| ▸ | CA1 | P00915 | 2/20 | 0.53 |
| ▸ | CA2 | P00918 | 2/20 | 0.53 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.50 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.48 |
| ▸ | KDM1A | O60341 | 1/20 | 0.48 |
| ▸ | GPR27 | Q9NS67 | 1/20 | 0.46 |
| ▸ | AR | P10275 | 1/20 | 0.46 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.45 |
| ▸ | PGR | P06401 | 1/20 | 0.44 |
| ▸ | ATIC | P31939 | 1/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.43 |
| ▸ | IDH1 | O75874 | 1/20 | 0.42 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.42 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.41 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7572618 | 0.81 | PKM (0.70) | PKMCA1CA2SLC40A1 | |
| SCHEMBL7591642 | 0.80 | ACLY (0.48) | PKMSLC22A12CA1CA2PTGES2 | |
| SCHEMBL7579145 | 0.79 | PKM (0.83) | PKMCA1CA2PGRSLC40A1 | |
| SCHEMBL7569548 | 0.78 | PKM (0.66) | PKMCA1CA2CYP19A1PTGES2 | |
| SCHEMBL96565 | 0.78 | PKM (0.66) | PKMCA1CA2SLC40A1BRD4 | |
| SCHEMBL7572258 | 0.75 | CYP19A1 (0.75) | PKMSLC22A12CA1CA2CYP19A1 | |
| SCHEMBL7571634 | 0.74 | SLC22A12 (0.53) | SLC22A12CA1CA2PTGES2KDM1A | |
| SCHEMBL14058523 | 0.73 | MAPT (0.60) | PKM | |
| SCHEMBL13631969 | 0.72 | MAP2K4 (0.65) | SLC22A12CYP19A1PTGES2KDM1AMAP2K4 | |
| SCHEMBL14645822 | 0.71 | CYP19A1 (0.75) | PKMSLC22A12CA1CA2CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1239852-A2 | BISSULFONAMIDE DERIVATIVES AS ENZYME INHIBITORS | Arrow Therapeutics Limited (GB) | 2002-09-18 | — | — | EP | disclosed |
| WO-2001028537-A2 | BISSULFONAMIDE DERIVATIVES AS ENZYME INHIBITORS | ARROW THERAPEUTICS LIMITED (GB) | 2001-04-26 | — | — | WO | disclosed |