Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 1/20 | 0.48 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 2/20 | 0.39 |
| ▸ | ABCB1 | P08183 | 4/20 | 0.38 |
| ▸ | HTR7 | P34969 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | SUV39H2 | Q9H5I1 | 1/20 | 0.36 |
| ▸ | HRH2 | P25021 | 1/20 | 0.36 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7593291 | 0.90 | LMNA (0.44) | TGFBR1ACVR1LMNASMN1; SMN2KDM4E | |
| SCHEMBL7583528 | 0.81 | TGFBR1 (0.47) | TGFBR1ACVR1LMNASMN1; SMN2KDM4E | |
| SCHEMBL7582076 | 0.80 | DRD2 (0.47) | LMNAKDM4EDRD2HTR7MAPT | |
| SCHEMBL7583969 | 0.79 | CHRNA7 (0.48) | LMNADRD2HTR7MAPT | |
| SCHEMBL7582907 | 0.79 | KDM4E (0.42) | TGFBR1ACVR1LMNAKDM4EHTR7 | |
| SCHEMBL7586646 | 0.79 | KDM4E (0.40) | LMNASMN1; SMN2KDM4EMAPK1DRD2 | |
| SCHEMBL7584847 | 0.77 | SMN1; SMN2 (0.40) | LMNASMN1; SMN2KDM4EMAPK1DRD2 | |
| SCHEMBL7586374 | 0.77 | CHRNA7 (0.46) | TGFBR1ACVR1LMNADRD2HTR7 | |
| SCHEMBL7587098 | 0.75 | CHRNA7 (0.44) | TGFBR1ACVR1LMNASMN1; SMN2KDM4E | |
| SCHEMBL7581209 | 0.74 | HTR7 (0.44) | LMNASMN1; SMN2KDM4EMAPK1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0675118-B1 | Biphenylderivatives, process for their preparation and their use as medicaments | EISAI CO LTD (JP) | 2002-10-09 | — | — | EP | claimed |
| EP-0675118-A2 | Biphenylderivatives, process for their preparation and their use as medicaments | Eisai Co., Ltd. (JP) | 1995-10-04 | — | — | EP | claimed |
| EP-0675118-B1 | Biphenylderivatives, process for their preparation and their use as medicaments | EISAI CO LTD (JP) | 2002-10-09 | — | — | EP | disclosed |
| US-6281214-B1 | USEFUL FOR TREATING AND AMELIORATING MENTAL DISORDERS | EISAI CO., LTD (JP) | 2001-08-28 | — | — | US | disclosed |
| EP-0675118-A2 | Biphenylderivatives, process for their preparation and their use as medicaments | Eisai Co., Ltd. (JP) | 1995-10-04 | — | — | EP | disclosed |