Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 3/20 | 0.33 |
| ▸ | HTR2C | P28335 | 3/20 | 0.33 |
| ▸ | HTR2B | P41595 | 3/20 | 0.33 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.30 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.30 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methane SCHEMBL7585776 | 0.98 | HTR2A (0.33) | HTR2AHTR2CHTR2BACVR1BTGFBR1 | |
| Ethane SCHEMBL7584566 | 0.81 | HTR2A (0.38) | HTR2AHTR2CHTR2B | |
| SCHEMBL7582099 | 0.74 | OPRD1 (0.36) | HTR2AHTR2CHTR2B | |
| SCHEMBL7958105 | 0.72 | NR1H4 (0.34) | HTR2AHTR2CHTR2B | |
| SCHEMBL7581298 | 0.71 | HTR7 (0.35) | HTR2AHTR2CHTR2B | |
| SCHEMBL7582143 | 0.71 | CHRM3 (0.41) | HTR2AHTR2CHTR2B | |
| SCHEMBL7588002 | 0.70 | HTR2C (0.40) | HTR2AHTR2CHTR2B | |
| SCHEMBL7583440 | 0.70 | HTR2C (0.38) | HTR2AHTR2CHTR2BTGFBR1ACVR1 | |
| Ethane SCHEMBL7584694 | 0.70 | P2RX7 (0.39) | HTR2B | |
| SCHEMBL10569759 | 0.70 | ALDH1A1 (0.43) | HTR2AHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0675118-B1 | Biphenylderivatives, process for their preparation and their use as medicaments | EISAI CO LTD (JP) | 2002-10-09 | — | — | EP | claimed |
| EP-0675118-A2 | Biphenylderivatives, process for their preparation and their use as medicaments | Eisai Co., Ltd. (JP) | 1995-10-04 | — | — | EP | claimed |
| EP-0675118-B1 | Biphenylderivatives, process for their preparation and their use as medicaments | EISAI CO LTD (JP) | 2002-10-09 | — | — | EP | disclosed |
| US-6281214-B1 | USEFUL FOR TREATING AND AMELIORATING MENTAL DISORDERS | EISAI CO., LTD (JP) | 2001-08-28 | — | — | US | disclosed |
| US-5849912-A | Biphenyl derivatives | EISAI CO., LTD. (JP) | 1998-12-15 | — | — | US | disclosed |
| EP-0675118-A2 | Biphenylderivatives, process for their preparation and their use as medicaments | Eisai Co., Ltd. (JP) | 1995-10-04 | — | — | EP | disclosed |