Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.77 |
| ▸ | LMNA | P02545 | 1/20 | 0.77 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.77 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tromethamine SCHEMBL11444147 | 0.92 | MEN1 (0.77) | MEN1LMNAKMT2AALDH1A1TSHR | |
| Tromethamine SCHEMBL1533756 | 0.92 | MEN1 (0.91) | MEN1LMNAKMT2AS1PR1KDM4E | |
| Tromethamine SCHEMBL445853 | 0.92 | MEN1 (0.91) | MEN1LMNAKMT2AS1PR1KDM4E | |
| Tromethamine SCHEMBL9580813 | 0.92 | MEN1 (0.91) | MEN1LMNAKMT2AS1PR1KDM4E | |
| Tromethamine SCHEMBL2313359 | 0.92 | MEN1 (0.91) | MEN1LMNAKMT2AS1PR1KDM4E | |
| Tromethamine SCHEMBL1270294 | 0.92 | MEN1 (0.91) | MEN1LMNAKMT2AS1PR1KDM4E | |
| Tromethamine SCHEMBL1524832 | 0.92 | MEN1 (0.91) | MEN1LMNAKMT2AS1PR1KDM4E | |
| Tromethamine SCHEMBL2188 | 0.92 | — | — | |
| Tromethamine SCHEMBL1417748 | 0.88 | MEN1 (0.83) | MEN1LMNAKMT2AS1PR1KDM4E | |
| Tromethamine SCHEMBL7193878 | 0.88 | MEN1 (0.83) | MEN1LMNAKMT2AS1PR1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9644029-B2 | Cancer diagnosis and treatment of cancer using anti-ROBO1 antibody | Aburatani, Hiroyuki (JP) | 2017-05-09 | — | — | US | disclosed |
| US-20150291694-A1 | Cancer Diagnosis and Treatment of Cancer Using Anti-Robo 1 Antibody | Aburatani, Hiroyuki (JP) | 2015-10-15 | — | — | US | disclosed |
| US-8940488-B2 | Cancer diagnosis and treatment of cancer using anti-robo 1 antibody | Aburatani, Hiroyuki (JP) | 2015-01-27 | — | — | US | disclosed |
| EP-2226636-B1 | Cancer diagnosis and treatment using anti-robo1 antibody | ABURATANI HIROYUKI (JP) | 2012-03-21 | — | — | EP | disclosed |
| EP-2226636-A1 | Cancer diagnosis and treatment using anti-robo1 antibody | Aburatani, Hiroyuki (JP) | 2010-09-08 | — | — | EP | disclosed |
| EP-1744162-B1 | CANCER DIAGNOSIS AND TREATMENT USING ANTI-ROBO1 ANTIBODY | ABURATANI HIROYUKI (JP) | 2010-08-04 | — | — | EP | disclosed |
| US-20070212359-A1 | Cancer Diagnosis And Treatment Of Cancer Using Anti-Robo 1 Antibody | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2007-09-13 | — | — | US | disclosed |
| EP-1744162-A1 | CANCER DIAGNOSIS AND TREATMENT USING ANTI-ROBO1 ANTIBODY | Aburatani, Hiroyuki (JP) | 2007-01-17 | — | — | EP | disclosed |