Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | F10 | P00742 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7590797 | 0.92 | L3MBTL1 (0.40) | ALDH1A1MAPTCYP3A4SMN1; SMN2CYP1A2 | |
| SCHEMBL7585660 | 0.90 | ADRB2 (0.44) | ALDH1A1MAPK1MAPTCYP3A4SMN1; SMN2 | |
| SCHEMBL7584283 | 0.87 | GAA (0.40) | ALDH1A1CYP3A4CYP1A2NPC1RAB9A | |
| SCHEMBL7583126 | 0.87 | ADRB2 (0.39) | ALDH1A1MAPK1MAPTCYP3A4L3MBTL1 | |
| SCHEMBL7589686 | 0.85 | CYP3A4 (0.44) | CYP3A4LMNA | |
| SCHEMBL7583539 | 0.84 | CYP3A4 (0.42) | MAPTCYP3A4NPC1RAB9AHDAC1 | |
| SCHEMBL7582260 | 0.83 | CYP3A4 (0.42) | CYP3A4SMN1; SMN2LMNAMRGPRX4 | |
| SCHEMBL7583085 | 0.83 | CYP3A4 (0.45) | ALDH1A1MAPTCYP3A4SMN1; SMN2CYP1A2 | |
| SCHEMBL7584819 | 0.82 | ADRB2 (0.39) | ALDH1A1MAPK1MAPTCYP3A4SMN1; SMN2 | |
| SCHEMBL7587071 | 0.82 | CYP3A4 (0.42) | CYP3A4LMNAKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0810218-B1 | 6-Benzyl-2H-pyridazin-3-one derivatives,their preparation and their use as inhibitors of prostaglandin G/H synthase I and II (COX I and COX II) | HOFFMANN LA ROCHE (CH) | 2002-12-04 | — | — | EP | disclosed |
| EP-0810218-A1 | 6-Benzyl-2H-pyridazin-3-one derivatives,their preparation and their use as inhibitors of prostaglandin G/H synthase I and II (COX I and COX II) | F. HOFFMANN-LA ROCHE AG (CH) | 1997-12-03 | — | — | EP | disclosed |