Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 3/20 | 0.42 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.38 |
| ▸ | AKR1B1 | P15121 | 8/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | WDR5 | P61964 | 1/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | THRA | P10827 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7589686 | 0.91 | CYP3A4 (0.44) | CYP3A4AKR1B1EPHX2LMNAPOLB | |
| SCHEMBL7583085 | 0.88 | CYP3A4 (0.45) | CYP3A4AKR1B1EPHX2LMNAPOLB | |
| SCHEMBL7587071 | 0.87 | CYP3A4 (0.42) | CYP3A4AKR1B1EPHX2LMNAPOLB | |
| SCHEMBL7583539 | 0.87 | CYP3A4 (0.42) | CYP3A4MRGPRX4AKR1B1EPHX2LMNA | |
| SCHEMBL7585660 | 0.84 | ADRB2 (0.44) | CYP3A4LMNAPOLBWDR5SMN1; SMN2 | |
| SCHEMBL7583097 | 0.83 | ALDH1A1 (0.41) | CYP3A4MRGPRX4LMNASMN1; SMN2 | |
| SCHEMBL7590797 | 0.81 | L3MBTL1 (0.40) | CYP3A4MRGPRX4POLBSMN1; SMN2THRA | |
| SCHEMBL7584283 | 0.80 | GAA (0.40) | CYP3A4MRGPRX4THRB | |
| SCHEMBL7585620 | 0.80 | CYP3A4 (0.55) | CYP3A4MRGPRX4POLB | |
| SCHEMBL7584819 | 0.77 | ADRB2 (0.39) | CYP3A4POLBWDR5SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0810218-B1 | 6-Benzyl-2H-pyridazin-3-one derivatives,their preparation and their use as inhibitors of prostaglandin G/H synthase I and II (COX I and COX II) | HOFFMANN LA ROCHE (CH) | 2002-12-04 | — | — | EP | claimed |
| EP-0810218-A1 | 6-Benzyl-2H-pyridazin-3-one derivatives,their preparation and their use as inhibitors of prostaglandin G/H synthase I and II (COX I and COX II) | F. HOFFMANN-LA ROCHE AG (CH) | 1997-12-03 | — | — | EP | claimed |
| EP-0810218-B1 | 6-Benzyl-2H-pyridazin-3-one derivatives,their preparation and their use as inhibitors of prostaglandin G/H synthase I and II (COX I and COX II) | HOFFMANN LA ROCHE (CH) | 2002-12-04 | — | — | EP | disclosed |
| US-5886178-A | ADMINISTERING OF A PROSTAGLANDIN G/H SYNTHASE INHIBITOR TO A PATIENT TO TREAT INFLAMMATORY OR AUTOIMMUNE DISEASES | SYNTEX (U.S.A.) INC. (US) | 1999-03-23 | — | — | US | disclosed |
| EP-0810218-A1 | 6-Benzyl-2H-pyridazin-3-one derivatives,their preparation and their use as inhibitors of prostaglandin G/H synthase I and II (COX I and COX II) | F. HOFFMANN-LA ROCHE AG (CH) | 1997-12-03 | — | — | EP | disclosed |