Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.35 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.34 |
| ▸ | THRA | P10827 | 1/20 | 0.34 |
| ▸ | F10 | P00742 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7583097 | 0.92 | ALDH1A1 (0.41) | L3MBTL1ALDH1A1MAPTUSP2CYP3A4 | |
| SCHEMBL7585660 | 0.88 | ADRB2 (0.44) | POLBALDH1A1MAPTHTTCYP3A4 | |
| SCHEMBL7584283 | 0.85 | GAA (0.40) | ALDH1A1CYP3A4TDP1ADRB2MRGPRX4 | |
| SCHEMBL7589686 | 0.83 | CYP3A4 (0.44) | POLBHTTCYP3A4THRA | |
| SCHEMBL7583539 | 0.82 | CYP3A4 (0.42) | POLBMAPTCYP3A4MRGPRX4THRA | |
| SCHEMBL7583126 | 0.82 | ADRB2 (0.39) | L3MBTL1POLBALDH1A1MAPTHTT | |
| SCHEMBL7583085 | 0.81 | CYP3A4 (0.45) | L3MBTL1POLBALDH1A1MAPTUSP2 | |
| SCHEMBL7582260 | 0.81 | CYP3A4 (0.42) | POLBCYP3A4SMN1; SMN2MRGPRX4THRA | |
| SCHEMBL7584819 | 0.81 | ADRB2 (0.39) | L3MBTL1POLBALDH1A1MAPTCYP3A4 | |
| SCHEMBL8505616 | 0.80 | L3MBTL1 (0.42) | L3MBTL1POLBALDH1A1MAPTUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0810218-B1 | 6-Benzyl-2H-pyridazin-3-one derivatives,their preparation and their use as inhibitors of prostaglandin G/H synthase I and II (COX I and COX II) | HOFFMANN LA ROCHE (CH) | 2002-12-04 | — | — | EP | disclosed |
| EP-0810218-A1 | 6-Benzyl-2H-pyridazin-3-one derivatives,their preparation and their use as inhibitors of prostaglandin G/H synthase I and II (COX I and COX II) | F. HOFFMANN-LA ROCHE AG (CH) | 1997-12-03 | — | — | EP | disclosed |