Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 5/20 | 0.46 |
| ▸ | DRD2 | P14416 | 7/20 | 0.43 |
| ▸ | DRD3 | P35462 | 6/20 | 0.43 |
| ▸ | DRD4 | P21917 | 5/20 | 0.43 |
| ▸ | HRH2 | P25021 | 5/20 | 0.43 |
| ▸ | HRH1 | P35367 | 4/20 | 0.43 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7583389 | 0.89 | HTR7 (0.43) | HTR7DRD2DRD3DRD4HRH2 | |
| SCHEMBL7581209 | 0.88 | HTR7 (0.44) | HTR7DRD2DRD3DRD4HRH2 | |
| SCHEMBL7583969 | 0.86 | CHRNA7 (0.48) | HTR7DRD2DRD3DRD4CHRNA7 | |
| SCHEMBL7584847 | 0.82 | SMN1; SMN2 (0.40) | HTR7DRD2CHRNA7POLBKDM4E | |
| SCHEMBL7593291 | 0.82 | LMNA (0.44) | DRD2CHRNA7POLBKMT2AKDM4E | |
| SCHEMBL7582076 | 0.81 | DRD2 (0.47) | HTR7DRD2CHRNA7POLBKMT2A | |
| SCHEMBL7586646 | 0.79 | KDM4E (0.40) | HTR7DRD2DRD3DRD4CHRNA7 | |
| SCHEMBL7584437 | 0.78 | CHRNA7 (0.47) | HTR7DRD2DRD3DRD4CHRNA7 | |
| SCHEMBL7586374 | 0.77 | CHRNA7 (0.46) | HTR7DRD2DRD3DRD4CHRNA7 | |
| SCHEMBL7582907 | 0.77 | KDM4E (0.42) | HTR7CHRNA7POLBKDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0675118-B1 | Biphenylderivatives, process for their preparation and their use as medicaments | EISAI CO LTD (JP) | 2002-10-09 | — | — | EP | claimed |
| EP-0675118-A2 | Biphenylderivatives, process for their preparation and their use as medicaments | Eisai Co., Ltd. (JP) | 1995-10-04 | — | — | EP | claimed |
| EP-0675118-B1 | Biphenylderivatives, process for their preparation and their use as medicaments | EISAI CO LTD (JP) | 2002-10-09 | — | — | EP | disclosed |
| US-6281214-B1 | USEFUL FOR TREATING AND AMELIORATING MENTAL DISORDERS | EISAI CO., LTD (JP) | 2001-08-28 | — | — | US | disclosed |
| EP-0675118-A2 | Biphenylderivatives, process for their preparation and their use as medicaments | Eisai Co., Ltd. (JP) | 1995-10-04 | — | — | EP | disclosed |