Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 10/20 | 0.51 |
| ▸ | RAB9A | P51151 | 9/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.46 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.46 |
| ▸ | RELA | Q04206 | 1/20 | 0.46 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.46 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.46 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | PNLIP | P16233 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL483177 | 0.86 | RAB9A (0.49) | RAB9ALMNAHTTKMT2AMEN1 | |
| SCHEMBL2701740 | 0.85 | FADS1 (0.53) | NPC1RAB9ALMNAHTTKMT2A | |
| SCHEMBL27499232 | 0.85 | LMNA (0.53) | NPC1RAB9ALMNAHTTKMT2A | |
| SCHEMBL11410940 | 0.83 | NPC1 (0.57) | NPC1RAB9ALMNAHTTMAPK1 | |
| SCHEMBL7578629 | 0.83 | RAB9A (0.54) | NPC1RAB9ALMNAHTTKMT2A | |
| SCHEMBL10388406 | 0.80 | P2RX1 (0.53) | NPC1RAB9ALMNAHTTMAPK1 | |
| SCHEMBL28142622 | 0.80 | RAB9A (0.60) | NPC1RAB9ALMNAKMT2AMEN1 | |
| SCHEMBL7576082 | 0.79 | MAPK1 (0.49) | NPC1RAB9ALMNAHTTMAPK1 | |
| SCHEMBL7578806 | 0.77 | CYP1A2 (0.57) | NPC1RAB9AKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL1196438 | 0.77 | TMPRSS4 (0.50) | NPC1RAB9ALMNAHTTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0882730-B1 | PHOSPHONIC ACID DIESTER DERIVATIVES | OTSUKA PHARMA CO LTD (JP) | 2002-10-02 | — | — | EP | disclosed |
| US-5985858-A | TREATING AND PREVENTING HYPERLIPIDEMIA, DIABETES AND CATARACT, OR AS AN ANTITUMOR AGENT | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1999-11-16 | — | — | US | disclosed |
| EP-0882730-A1 | PHOSPHONIC ACID DIESTER DERIVATIVES | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1998-12-09 | — | — | EP | disclosed |