Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 5/20 | 0.57 |
| ▸ | RORC | P51449 | 2/20 | 0.57 |
| ▸ | THRA | P10827 | 3/20 | 0.55 |
| ▸ | AR | P10275 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | PGR | P06401 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22959249 | 0.88 | RORC (0.73) | THRBRORCTHRAHTTLMNA | |
| SCHEMBL7097286 | 0.85 | THRB (0.75) | THRBRORCTHRA | |
| SCHEMBL6765992 | 0.84 | AR (0.52) | THRBTHRAARHTTRAB9A | |
| SCHEMBL7094647 | 0.83 | THRB (0.61) | THRBRORCTHRA | |
| SCHEMBL8799875 | 0.82 | THRB (0.60) | THRBRORCTHRA | |
| SCHEMBL8892202 | 0.82 | THRB (0.54) | THRBRORCTHRA | |
| SCHEMBL8798523 | 0.81 | THRB (0.54) | THRBRORCTHRA | |
| SCHEMBL282165 | 0.81 | THRB (0.53) | THRBRORCTHRA | |
| SCHEMBL282114 | 0.80 | THRB (0.51) | THRBRORCTHRA | |
| SCHEMBL8912986 | 0.79 | THRB (0.56) | THRBRORCTHRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1183074-A1 | SUBSTITUTED BIARYL ETHER COMPOUNDS | UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER (US) | 2002-03-06 | — | — | EP | disclosed |
| WO-2000072920-A1 | SUBSTITUTED BIARYL ETHER COMPOUNDS | THE UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER (US) | 2000-12-07 | — | — | WO | disclosed |