Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.43 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | CHRNB2 | P17787 | 4/20 | 0.42 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.38 |
| ▸ | CDK4 | P11802 | 1/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.38 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.38 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7584881 | 0.99 | ALDH1A1 (0.42) | CHRM2CHRM4ADRB1CHRM1CHRM3 | |
| SCHEMBL7584894 | 0.85 | MEN1 (0.45) | ALDH1A1LMNAGAAMAPK1MAPT | |
| SCHEMBL19212046 | 0.82 | MAPT (0.46) | ADRB1ALDH1A1DYRK1AL3MBTL1LMNA | |
| SCHEMBL7585738 | 0.81 | MAPT (0.47) | ALDH1A1LMNAGAAMAPK1MAPT | |
| SCHEMBL3464205 | 0.80 | MAPT (0.54) | ADRB1ALDH1A1CHRNB2CHRNA4DYRK1A | |
| SCHEMBL5863451 | 0.77 | ADRB1 (0.55) | ADRB1ALDH1A1DYRK1AL3MBTL1LMNA | |
| SCHEMBL7587341 | 0.75 | ADRB1 (0.62) | CHRM2CHRM4ADRB1CHRM1CHRM3 | |
| SCHEMBL8352185 | 0.74 | ADRB1 (0.55) | ADRB1ALDH1A1DYRK1AL3MBTL1LMNA | |
| Tert-Butyl Formate SCHEMBL28258230 | 0.74 | ALDH1A1 (0.41) | ADRB1ALDH1A1DYRK1ALMNAGAA | |
| SCHEMBL17595153 | 0.74 | CYP1A2 (0.47) | CHRM2CHRM4ADRB1CHRM1CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0675118-B1 | Biphenylderivatives, process for their preparation and their use as medicaments | EISAI CO LTD (JP) | 2002-10-09 | — | — | EP | disclosed |
| US-6281214-B1 | USEFUL FOR TREATING AND AMELIORATING MENTAL DISORDERS | EISAI CO., LTD (JP) | 2001-08-28 | — | — | US | disclosed |
| US-5849912-A | Biphenyl derivatives | EISAI CO., LTD. (JP) | 1998-12-15 | — | — | US | disclosed |
| EP-0675118-A2 | Biphenylderivatives, process for their preparation and their use as medicaments | Eisai Co., Ltd. (JP) | 1995-10-04 | — | — | EP | disclosed |