Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 6/20 | 0.41 |
| ▸ | DRD2 | P14416 | 4/20 | 0.39 |
| ▸ | HTR2A | P28223 | 4/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 2/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7584388 | 0.88 | TP53 (0.43) | DRD2TP53LMNATHRBHTR1A | |
| SCHEMBL7589752 | 0.85 | DRD2 (0.36) | DRD2HTR2AHTR1AHTR7 | |
| SCHEMBL7583439 | 0.85 | CHRNA7 (0.39) | DRD2HTR2AHTR1A | |
| Hydrochloric Acid SCHEMBL7584884 | 0.84 | DRD2 (0.35) | DRD2HTR2AHTR1AHTR7 | |
| Hydrochloric Acid SCHEMBL7585021 | 0.84 | DRD2 (0.35) | DRD2HTR2AHTR1AHTR7 | |
| SCHEMBL7584813 | 0.84 | HTR6 (0.39) | HTR2A | |
| SCHEMBL7588266 | 0.79 | CYP1A2 (0.38) | DRD2HTR2ATP53LMNATHRB | |
| SCHEMBL7590706 | 0.79 | CYP1A2 (0.38) | DRD2HTR2ATP53LMNATHRB | |
| SCHEMBL7585740 | 0.73 | DRD2 (0.44) | DRD2HTR2ALMNAHTR1AHTR7 | |
| SCHEMBL7583679 | 0.73 | DRD2 (0.44) | DRD2LMNAHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0675118-B1 | Biphenylderivatives, process for their preparation and their use as medicaments | EISAI CO LTD (JP) | 2002-10-09 | — | — | EP | claimed |
| EP-0675118-A2 | Biphenylderivatives, process for their preparation and their use as medicaments | Eisai Co., Ltd. (JP) | 1995-10-04 | — | — | EP | claimed |
| EP-0675118-B1 | Biphenylderivatives, process for their preparation and their use as medicaments | EISAI CO LTD (JP) | 2002-10-09 | — | — | EP | disclosed |
| US-6281214-B1 | USEFUL FOR TREATING AND AMELIORATING MENTAL DISORDERS | EISAI CO., LTD (JP) | 2001-08-28 | — | — | US | disclosed |
| EP-0675118-A2 | Biphenylderivatives, process for their preparation and their use as medicaments | Eisai Co., Ltd. (JP) | 1995-10-04 | — | — | EP | disclosed |