Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 2/20 | 0.38 |
| ▸ | DRD3 | P35462 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 3/20 | 0.34 |
| ▸ | HTR7 | P34969 | 3/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7588266 | 1.00 | CYP1A2 (0.38) | CYP1A2CYP3A4KDM4EMEN1LMNA | |
| SCHEMBL7584813 | 0.89 | HTR6 (0.39) | CYP1A2CYP3A4KDM4EMEN1MAPT | |
| SCHEMBL7583439 | 0.88 | CHRNA7 (0.39) | KDM4EMAPTDRD2DRD3SOS1 | |
| SCHEMBL7589752 | 0.84 | DRD2 (0.36) | MAPTDRD2DRD3OPRL1HTR1A | |
| Hydrochloric Acid SCHEMBL7584884 | 0.84 | DRD2 (0.35) | MAPTDRD2DRD3OPRL1HTR1A | |
| Hydrochloric Acid SCHEMBL7585021 | 0.84 | DRD2 (0.35) | MAPTDRD2DRD3OPRL1HTR1A | |
| SCHEMBL7585752 | 0.79 | RET (0.41) | LMNADRD2HTR1AHTR7HTR2A | |
| SCHEMBL7590671 | 0.74 | CHRNB2 (0.45) | CYP1A2CYP3A4DRD2DRD3HTR1A | |
| SCHEMBL7584867 | 0.74 | CHRNB2 (0.45) | CYP1A2CYP3A4DRD2DRD3HTR1A | |
| SCHEMBL7584119 | 0.73 | TACR1 (0.39) | CYP1A2CYP3A4MEN1LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0675118-B1 | Biphenylderivatives, process for their preparation and their use as medicaments | EISAI CO LTD (JP) | 2002-10-09 | — | — | EP | disclosed |
| US-6281214-B1 | USEFUL FOR TREATING AND AMELIORATING MENTAL DISORDERS | EISAI CO., LTD (JP) | 2001-08-28 | — | — | US | disclosed |
| EP-0675118-A2 | Biphenylderivatives, process for their preparation and their use as medicaments | Eisai Co., Ltd. (JP) | 1995-10-04 | — | — | EP | disclosed |