SCHEMBL7588340

SCHEMBL7588340

COCOc1ccc(C2COc3cc(OCOC)ccc3C2c2cccc(OCCCCCCl)c2)cc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ESR1 P03372 4/20 0.47
ESR2 Q92731 3/20 0.47
PPARG P37231 12/20 0.41
PPARD Q03181 12/20 0.41
FFAR1 O14842 9/20 0.39
PPARA Q07869 1/20 0.37
DRD3 P35462 2/20 0.36
PGR P06401 1/20 0.36
CHRM2 P08172 1/20 0.36
HTR1A P08908 1/20 0.36
ADRA2A P08913 1/20 0.36
ADORA3 P0DMS8 1/20 0.36
CHRM1 P11229 1/20 0.36
DRD1 P21728 1/20 0.36
TBXA2R P21731 1/20 0.36
PTGS1 P23219 1/20 0.36
SLC6A2 P23975 1/20 0.36
SLC6A4 P31645 1/20 0.36
ADRA1A P35348 1/20 0.36
OPRM1 P35372 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7589458 0.91 ESR1 (0.46) ESR1ESR2PPARGPPARDFFAR1
SCHEMBL8519738 0.91 ESR1 (0.42) ESR1ESR2PPARGPPARDFFAR1
SCHEMBL7590331 0.84 ESR1 (0.41) ESR1ESR2PPARGPPARDFFAR1
SCHEMBL6895259 0.80 ESR1 (0.57) ESR1ESR2PPARGPPARDFFAR1
SCHEMBL6902084 0.76 ESR1 (0.59) ESR1ESR2PPARGPPARDFFAR1
SCHEMBL7587937 0.76 PPARG (0.36) ESR1ESR2PPARGPPARDFFAR1
SCHEMBL2007995 0.74 CYP3A4 (0.46) ESR1ESR2PPARGPPARDFFAR1
SCHEMBL7585298 0.73 PPARG (0.36) PPARGPPARDFFAR1PPARAMAPT
SCHEMBL6900049 0.73 ESR1 (0.55) ESR1ESR2PPARGPPARDFFAR1
SCHEMBL6901973 0.73 ESR1 (0.55) ESR1ESR2PPARGPPARDFFAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1120162-C Novel benzopyran derivatives CHUGAI PHARMACEUTICAL CO LTD (JP) 2003-09-03 CN disclosed
EP-0944613-B1 BENZOPYRAN DERIVATIVES CHUGAI PHARMACEUTICAL CO LTD (JP) 2002-10-09 EP disclosed
US-6153768-A RECEPTOR BLOCKING ANTIESTROGENS HAVING REDUCED SIDE EFFECTS C & C RESEARCH LABORATORIES (KR) 2000-11-28 US disclosed
CN-1244863-A Novel benzopyran derivatives C & C RESEARCH LAB (KR) 2000-02-16 CN disclosed
EP-0944613-A1 NOVEL BENZOPYRAN DERIVATIVES C & C Research Laboratories (KR) 1999-09-29 EP disclosed
WO-1998025916-A1 NOVEL BENZOPYRAN DERIVATIVES C & C RESEARCH LABORATORIES (KR) 1998-06-18 WO disclosed