SCHEMBL7588445

SCHEMBL7588445

COc1nc(C)nc(NC(=O)NS(=O)(=O)c2ccsc2C(=O)O)n1.C[C@H](OC(=O)c1cc(Oc2ccc(C(F)(F)F)cc2Cl)ccc1Cl)C(=O)O

nearest known ligand 0.42

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.35
KDM4E B2RXH2 1/20 0.35
GAA P10253 1/20 0.35
MAPT P10636 1/20 0.35
HPGD P15428 1/20 0.35
MEN1 O00255 1/20 0.35
TTR P02766 1/20 0.35
PPOX P50336 1/20 0.35
KMT2A Q03164 1/20 0.35
TDP1 Q9NUW8 1/20 0.35
THRB P10828 1/20 0.35
FFAR1 O14842 2/20 0.33
EDNRA P25101 4/20 0.32
SCN8A Q9UQD0 1/20 0.31
SCN10A Q9Y5Y9 1/20 0.31
MCL1 Q07820 1/20 0.31
EDNRB P24530 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Thifensulfuron-Methyl SCHEMBL7582910 0.96 LMNA (0.35) LMNAKDM4EGAAMAPTHPGD
Glyphosate SCHEMBL7584931 0.93 EDNRA (0.31) LMNAKDM4EGAAMAPTHPGD
Glufosinate SCHEMBL7580731 0.92 KDM4E (0.30) LMNAKDM4EGAAMAPTHPGD
SCHEMBL7578244 0.90 KDM4E (0.31) KDM4EMAPTMEN1KMT2A
SCHEMBL7582061 0.90 MEN1 (0.37) LMNAKDM4EGAAMAPTHPGD
Chlorsulfuron SCHEMBL7578067 0.90 KDM4E (0.38) LMNAKDM4EGAAMAPTHPGD
Iodosulfuron SCHEMBL7586575 0.88 LMNA (0.36) LMNAKDM4EGAAMAPTHPGD
Lactofen SCHEMBL7583220 0.87 TDP1 (0.43) LMNAKDM4EGAAMAPTHPGD
Prosulfuron SCHEMBL7575335 0.86 LMNA (0.34) LMNAKDM4EGAAMAPTHPGD
Acifluorfen SCHEMBL7577323 0.85 TDP1 (0.54) LMNAMEN1TTRPPOXKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20020004457-A1 Herbicidal composition SYNGENTA PARTICIPATIONS AG (CH) 2002-01-10 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020004457-A1 Herbicidal composition PPOX, ALAD, DDT LMNA 3881/4885KDM4E 1886/4885GAA 288/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.