Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | IKBKB | O14920 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 2/20 | 0.35 |
| ▸ | C1S | P09871 | 1/20 | 0.34 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.34 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7536844 | 0.76 | SIRT1 (0.38) | KMT2AMEN1L3MBTL1KDM4EALDH1A1 | |
| SCHEMBL7597754 | 0.75 | ALDH1A1 (0.33) | KMT2AMEN1POLBL3MBTL1KDM4E | |
| SCHEMBL1842323 | 0.74 | NPC1 (0.52) | KMT2AMEN1POLBL3MBTL1KDM4E | |
| SCHEMBL27586338 | 0.74 | ALDH1A1 (0.45) | KMT2AMEN1POLBKDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL1844041 | 0.73 | NPC1 (0.51) | KMT2AMEN1POLBL3MBTL1KDM4E | |
| SCHEMBL6067890 | 0.72 | NPC1 (0.59) | KMT2AMEN1ALDH1A1GAA | |
| SCHEMBL27570327 | 0.68 | ALDH1A1 (0.36) | KMT2AMEN1POLBALDH1A1LMNA | |
| SCHEMBL7242715 | 0.65 | ALDH1A1 (0.40) | KMT2AMEN1POLBL3MBTL1ALDH1A1 | |
| SCHEMBL27566816 | 0.65 | NPC1 (0.44) | KMT2AMEN1KDM4ELMNATP53 | |
| SCHEMBL16975325 | 0.65 | ALDH1A1 (0.52) | KMT2AMEN1POLBL3MBTL1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1254123-A1 | 2-BENZOTHIAZOLYL UREA DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | Abbott GmbH & Co. KG (DE) | 2002-11-06 | — | — | EP | disclosed |
| WO-2001057008-A1 | 2-BENZOTHIAZOLYL UREA DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | ABBOTT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG & COMPANY KOMMANDITGESELLSCHAFT (DE) | 2001-08-09 | — | — | WO | disclosed |