Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.33 |
| ▸ | TSHR | P16473 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.33 |
| ▸ | MEN1 | O00255 | 5/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 3/20 | 0.32 |
| ▸ | RAB9A | P51151 | 3/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | CASP3 | P42574 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.32 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.32 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.32 |
| ▸ | NSD2 | O96028 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7536844 | 0.76 | SIRT1 (0.38) | ALDH1A1TSHRKDM4EHSD17B10TDP1 | |
| SCHEMBL7588936 | 0.75 | KMT2A (0.40) | ALDH1A1TSHRKDM4EHSD17B10TDP1 | |
| SCHEMBL27586272 | 0.75 | MEN1 (0.41) | ALDH1A1KDM4EKMT2AMEN1GAA | |
| SCHEMBL1842323 | 0.73 | NPC1 (0.52) | ALDH1A1TSHRKDM4EHSD17B10TDP1 | |
| SCHEMBL6068378 | 0.72 | NPC1 (0.58) | KMT2AMEN1GAANPC1RAB9A | |
| Hydrochloric Acid SCHEMBL1844041 | 0.72 | NPC1 (0.51) | ALDH1A1TSHRKDM4EHSD17B10TDP1 | |
| SCHEMBL27570327 | 0.69 | ALDH1A1 (0.36) | ALDH1A1KMT2AMEN1LMNATP53 | |
| SCHEMBL7242715 | 0.67 | ALDH1A1 (0.40) | ALDH1A1TSHRL3MBTL1KMT2AMEN1 | |
| SCHEMBL27566816 | 0.65 | NPC1 (0.44) | KDM4EKMT2AMEN1NPC1RAB9A | |
| SCHEMBL1292458 | 0.64 | MAOB (0.43) | L3MBTL1KMT2AMEN1LMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1254123-A1 | 2-BENZOTHIAZOLYL UREA DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | Abbott GmbH & Co. KG (DE) | 2002-11-06 | — | — | EP | disclosed |
| WO-2001057008-A1 | 2-BENZOTHIAZOLYL UREA DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | ABBOTT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG & COMPANY KOMMANDITGESELLSCHAFT (DE) | 2001-08-09 | — | — | WO | disclosed |