Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | DHFR | P00374 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.35 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.35 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.34 |
| ▸ | SELE | P16581 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7588936 | 0.76 | KMT2A (0.40) | ALDH1A1TSHRHSD17B10MEN1KMT2A | |
| SCHEMBL7597754 | 0.76 | ALDH1A1 (0.33) | ALDH1A1TSHRHSD17B10MEN1KMT2A | |
| SCHEMBL1842323 | 0.75 | NPC1 (0.52) | ALDH1A1TSHRHSD17B10MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL1844041 | 0.74 | NPC1 (0.51) | ALDH1A1TSHRHSD17B10MEN1KMT2A | |
| SCHEMBL27586270 | 0.73 | SIRT1 (0.43) | SIRT1ALDH1A1DHFRMEN1KMT2A | |
| SCHEMBL6067996 | 0.71 | NPC1 (0.60) | ALDH1A1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL7545430 | 0.70 | ALOX5 (0.32) | MEN1KMT2AALOX5CXCL12 | |
| SCHEMBL27570327 | 0.68 | ALDH1A1 (0.36) | ALDH1A1MEN1KMT2ALMNASMN1; SMN2 | |
| SCHEMBL27566816 | 0.66 | NPC1 (0.44) | MEN1KMT2ANPC1RAB9ALMNA | |
| SCHEMBL7242715 | 0.66 | ALDH1A1 (0.40) | ALDH1A1TSHRMEN1KMT2AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1254123-A1 | 2-BENZOTHIAZOLYL UREA DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | Abbott GmbH & Co. KG (DE) | 2002-11-06 | — | — | EP | disclosed |
| WO-2001057008-A1 | 2-BENZOTHIAZOLYL UREA DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | ABBOTT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG & COMPANY KOMMANDITGESELLSCHAFT (DE) | 2001-08-09 | — | — | WO | disclosed |