Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | CRHBP | P24387 | 1/20 | 0.51 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | CRHR1 | P34998 | 11/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HCN1 | O60741 | 2/20 | 0.41 |
| ▸ | HCN4 | Q9Y3Q4 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7511418 | 0.90 | MAPT (0.57) | MAPTCRHBPCRHR2NPSR1TP53 | |
| SCHEMBL7504044 | 0.81 | MAPT (0.51) | MAPTCRHBPCRHR2NPSR1TP53 | |
| SCHEMBL13752166 | 0.79 | MAPT (0.73) | MAPTCRHBPCRHR2NPSR1TP53 | |
| SCHEMBL9878999 | 0.79 | LMNA (0.50) | MAPTLMNAL3MBTL1HTTKMT2A | |
| SCHEMBL9004423 | 0.78 | ALDH1A1 (0.63) | MAPTCRHBPCRHR2NPSR1TP53 | |
| SCHEMBL7503109 | 0.78 | MAPT (0.50) | MAPTCRHBPCRHR2NPSR1TP53 | |
| SCHEMBL8894118 | 0.76 | L3MBTL1 (0.52) | MAPTCRHBPCRHR2NPSR1TP53 | |
| SCHEMBL9811161 | 0.75 | MAPT (0.58) | MAPTCRHBPCRHR2NPSR1TP53 | |
| SCHEMBL20476321 | 0.74 | TDP1 (0.46) | MAPTLMNACRHR1HTTKMT2A | |
| SCHEMBL8795503 | 0.74 | LMNA (0.45) | MAPTNPSR1LMNAL3MBTL1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1206265-A4 | SRC KINASE INHIBITOR COMPOUNDS | MERCK & CO INC (US) | 2002-08-07 | — | — | EP | disclosed |
| EP-1206265-A1 | SRC KINASE INHIBITOR COMPOUNDS | Merck & Co., Inc. (US) | 2002-05-22 | — | — | EP | disclosed |
| WO-2001000213-A1 | SRC KINASE INHIBITOR COMPOUNDS | MERCK & CO., INC. (US) | 2001-01-04 | — | — | WO | disclosed |