Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 20/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8518578 | 0.73 | P2RX7 (0.34) | CRHR1 | |
| SCHEMBL7597573 | 0.72 | KMT2A (0.40) | CRHR1 | |
| SCHEMBL4699275 | 0.71 | CRHR1 (0.52) | CRHR1 | |
| SCHEMBL12361015 | 0.70 | CRHR1 (0.49) | CRHR1 | |
| SCHEMBL14446399 | 0.68 | CRHR1 (1.00) | CRHR1 | |
| SCHEMBL5383551 | 0.67 | CRHR1 (1.00) | CRHR1 | |
| SCHEMBL14446397 | 0.67 | CRHR1 (1.00) | CRHR1 | |
| SCHEMBL5391880 | 0.67 | CRHR1 (1.00) | CRHR1 | |
| SCHEMBL5378408 | 0.67 | CRHR1 (1.00) | CRHR1 | |
| SCHEMBL5385547 | 0.66 | CRHR1 (0.83) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020042422-A1 | Certain pyrazole derivatives as corticotropin-releasing factor CRF1 ligands | NEUROGEN CORPORATION | 2002-04-11 | — | — | US | claimed |
| EP-0941223-A1 | CERTAIN PYRAZOLE DERIVATIVES AS CORTICOTROPIN-RELEASING FACTOR RECEPTOR CRF1 SPECIFIC LIGANDS | NEUROGEN CORPORATION (US) | 1999-09-15 | — | — | EP | claimed |
| US-5760225-A | DIAGNOSIS AND TREATMENT OF STRESS DISORDERS AND DEPRESSION | NEUROGEN CORPORATION (US) | 1998-06-02 | — | — | US | claimed |
| WO-1998021200-A1 | CERTAIN PYRAZOLE DERIVATIVES AS CORTICOTROPIN-RELEASING FACTOR RECEPTOR CRF1 SPECIFIC LIGANDS | NEUROGEN CORPORATION (US) | 1998-05-22 | — | — | WO | claimed |
| US-6300360-B1 | FOR THERAPY OF STRESS RELATED DISORDERS SUCH AS POST TRAUMATIC STRESS DISORDER (PTSD) AS WELL AS DEPRESSION, HEADACHE AND ANXIETY | NEUROGEN CORPORATION | 2001-10-09 | — | — | US | disclosed |
| US-6127399-A | TREATING POST TRAUMATIC STRESS DISORDER AS WELL AS DEPRESSION, HEADACHE AND ANXIETY | NEUROGEN CORPORATION (US) | 2000-10-03 | — | — | US | disclosed |
| US-5973152-A | Certain pyrazole derivatives as corticotropin-releasing factor receptor CRF1 specific ligands | NEUROGEN CORPORATION | 1999-10-26 | — | — | US | disclosed |
| US-5760225-A | DIAGNOSIS AND TREATMENT OF STRESS DISORDERS AND DEPRESSION | NEUROGEN CORPORATION (US) | 1998-06-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020042422-A1 | Certain pyrazole derivatives as corticotropin-releasing factor CRF1 ligands | CRH, CRHR1, CRHR2 | CRHR1 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.