Phthalimide

Phthalimide

SCHEMBL7590940

CCOC(N)=O.O=C1NC(=O)c2ccccc21

nearest known ligand 0.52

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX15 P16050 1/20 0.52
GSK3B P49841 1/20 0.52
IDO1 P14902 1/20 0.51
TDO2 P48775 1/20 0.51
ALDH1A1 P00352 8/20 0.46
KMT2A Q03164 4/20 0.46
MEN1 O00255 3/20 0.46
KDM4E B2RXH2 2/20 0.46
AGTR1 P30556 1/20 0.46
CYP1A2 P05177 2/20 0.46
CASP3 P42574 1/20 0.46
CASP2 P42575 1/20 0.46
CASP7 P55210 1/20 0.46
CASP6 P55212 1/20 0.46
CASP8 Q14790 1/20 0.46
TSHR P16473 1/20 0.43
HSD17B10 Q99714 1/20 0.41
TDP2 O95551 3/20 0.41
ATM Q13315 2/20 0.41
LMNA P02545 2/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Urethane SCHEMBL6557515 0.85 ALOX15 (0.65) ALOX15IDO1TDO2ALDH1A1KMT2A
Phthalimide SCHEMBL10495296 0.84 GSK3B (0.54) GSK3BIDO1TDO2ALDH1A1KMT2A
Malonic Acid Diethyl Ester SCHEMBL27904592 0.83 CYP1A2 (0.52) GSK3BIDO1TDO2ALDH1A1KMT2A
Diethyl Phthalate SCHEMBL27518710 0.81 TSHR (0.70) ALOX15GSK3BIDO1TDO2ALDH1A1
Phthalic Anhydride SCHEMBL28455726 0.81 ALDH1A1 (0.59) ALOX15IDO1TDO2ALDH1A1KMT2A
Phthalimide SCHEMBL11427744 0.79 L3MBTL1 (0.48) GSK3BIDO1TDO2ALDH1A1KMT2A
Saccharin SCHEMBL10384131 0.79 CA12 (0.63) ALOX15IDO1TDO2ALDH1A1KMT2A
Naphthalene SCHEMBL9435323 0.77 ALOX15 (0.65) ALOX15ALDH1A1KMT2AMEN1KDM4E
Phthalimide SCHEMBL8421052 0.77 GSK3B (0.65) ALOX15GSK3BIDO1TDO2ALDH1A1
O-Xylene SCHEMBL10812881 0.77 ALOX15 (0.65) ALOX15ALDH1A1KMT2AMEN1CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0772590-B1 THROMBIN INHIBITORS MERCK & CO INC (US) 2002-10-09 EP disclosed
EP-1023061-A4 SOMATOSTATIN AGONISTS MERCK & CO INC (US) 2001-04-11 EP disclosed
US-6117880-A TREATMENT OF DIABETES, RETINOPATHY, RESTINOSIS, ACROMEGALY, AND DEPRESSION MERCK & CO., INC. (US) 2000-09-12 US disclosed
EP-1023061-A1 SOMATOSTATIN AGONISTS Merck & Co., Inc. (US) 2000-08-02 EP disclosed
US-6057338-A USEFUL IN THE TREATMENT OF DIABETES, CANCER, ACROMEGALY, RESTENOSIS, DEPRESSION, IRRITABLE BOWEL SYNDROME, PAIN AND DIABETIC RETINOPATHY MERCK & CO., INC. (US) 2000-05-02 US disclosed
WO-1999022735-A1 SOMATOSTATIN AGONISTS MERCK & CO., INC. (US) 1999-05-14 WO disclosed
WO-1998044921-A1 SOMATOSTATIN AGONISTS MERCK & CO., INC. (US) 1998-10-15 WO disclosed
US-5714485-A Piperidine and hexahydropyridazine thrombin inhibitors MERCK & CO., INC. (US) 1998-02-03 US disclosed
US-5510369-A ANTICOAGULANTS MERCK & CO., INC. (US) 1996-04-23 US disclosed