Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1S known ✓ | Q13698 | 13/20 | 0.63 |
| ▸ | KCNH2 known ✓ | Q12809 | 2/20 | 0.51 |
| ▸ | CACNA1F known ✓ | O60840 | 1/20 | 0.51 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.51 |
| ▸ | CACNA1D known ✓ | Q01668 | 1/20 | 0.51 |
| ▸ | CACNA1C known ✓ | Q13936 | 1/20 | 0.51 |
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A known ✓ | Q03164 | 1/20 | 0.51 |
| ▸ | HTR2A known ✓ | P28223 | 1/20 | 0.42 |
| ▸ | HTR2C known ✓ | P28335 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.51 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.51 |
| ▸ | HRH2 | P25021 | 1/20 | 0.51 |
| ▸ | SCN1A | P35498 | 1/20 | 0.51 |
| ▸ | SCN4A | P35499 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL7590970 | 1.00 | CACNA1S (0.63) | CACNA1SCYP3A4TSHRABCB11LMNA | |
| Clentiazem SCHEMBL7266655 | 0.83 | CACNA1S (0.79) | CACNA1SCYP3A4TSHRABCB11LMNA | |
| Clentiazem SCHEMBL7267636 | 0.83 | CACNA1S (0.79) | CACNA1SCYP3A4TSHRABCB11LMNA | |
| Clentiazem SCHEMBL387182 | 0.83 | CACNA1S (0.79) | CACNA1SCYP3A4TSHRABCB11LMNA | |
| Clentiazem SCHEMBL387183 | 0.83 | CACNA1S (0.79) | CACNA1SCYP3A4TSHRABCB11LMNA | |
| Clentiazem SCHEMBL7266652 | 0.83 | CACNA1S (0.79) | CACNA1SCYP3A4TSHRABCB11LMNA | |
| SCHEMBL7291811 | 0.77 | CACNA1S (1.00) | CACNA1SCYP3A4TSHRABCB11LMNA | |
| Clentiazem SCHEMBL33910 | 0.77 | CACNA1S (0.86) | CACNA1SCYP3A4TSHRABCB11LMNA | |
| SCHEMBL7291802 | 0.77 | CACNA1S (1.00) | CACNA1SCYP3A4TSHRABCB11LMNA | |
| Clentiazem SCHEMBL33909 | 0.77 | CACNA1S (0.86) | CACNA1SCYP3A4TSHRABCB11LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0335560-B2 | Controlled release pharmaceutical preparation and method for producing the same | TANABE SEIYAKU CO (JP) | 2002-01-23 | — | — | EP | disclosed |
| EP-0335560-B1 | CONTROLLED RELEASE PHARMACEUTICAL PREPARATION AND METHOD FOR PRODUCING THE SAME | Tanabe Seiyaku Co., Ltd. (JP) | 1993-07-28 | — | — | EP | disclosed |
| US-5068112-A | Core containing active ingredient and succinic acid with surface porous film of cellulose | TANABE SEIYAKU CO., LTD. (JP) | 1991-11-26 | — | — | US | disclosed |