Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 6/20 | 0.46 |
| ▸ | HTR7 | P34969 | 5/20 | 0.46 |
| ▸ | DRD2 | P14416 | 4/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7586281 | 0.92 | HTR1A (0.45) | HTR1AHTR7DRD2MEN1KMT2A | |
| SCHEMBL7591765 | 0.90 | NPC1 (0.48) | HTR1AHTR7DRD2NPC1MAPT | |
| SCHEMBL7591807 | 0.90 | HTR1A (0.49) | HTR1AHTR7DRD2MAPTMEN1 | |
| SCHEMBL7583215 | 0.85 | NPC1 (0.41) | HTR1AHTR7DRD2TP53NPC1 | |
| SCHEMBL7159729 | 0.84 | AKT3 (0.50) | HTR1AHTR7DRD2TP53MAPT | |
| Hydrochloric Acid SCHEMBL7157979 | 0.83 | AKT3 (0.48) | HTR1AHTR7DRD2TP53MAPT | |
| SCHEMBL7587006 | 0.81 | NPBWR1 (0.46) | DRD2TP53NPC1MAPTMEN1 | |
| SCHEMBL7582824 | 0.76 | NPC1 (0.45) | HTR1AHTR7DRD2NPC1MAPT | |
| SCHEMBL7160985 | 0.76 | ESRRG (0.52) | HTR1AHTR7DRD2ALDH1A1DRD4 | |
| SCHEMBL7585905 | 0.75 | NPSR1 (0.48) | HTR1AHTR7DRD2TP53NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0957099-B1 | Heterocyclic carboxamides | PFIZER PROD INC (US) | 2002-11-20 | — | — | EP | claimed |