Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 2/20 | 0.46 |
| ▸ | HPGDS | O60760 | 2/20 | 0.45 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.45 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | ERN1 | O75460 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALPL | P05186 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | F2 | P00734 | 1/20 | 0.42 |
| ▸ | ST14 | Q9Y5Y6 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL736430 | 0.89 | ALDH1A1 (0.53) | BRD4HPGDSLMNAMAPK14ALDH1A1 | |
| SCHEMBL738916 | 0.89 | ALDH1A1 (0.53) | BRD4HPGDSLMNAMAPK14ALDH1A1 | |
| SCHEMBL758810 | 0.87 | KMT2A (0.43) | LRRK2LMNAMAPK14ALDH1A1SMN1; SMN2 | |
| SCHEMBL9964597 | 0.86 | AURKA (0.51) | BRD4LRRK2PTK2 | |
| SCHEMBL15493973 | 0.80 | MAPK14 (0.51) | BRD4HPGDSMAPK14SMN1; SMN2MEN1 | |
| SCHEMBL13175562 | 0.79 | BRD4 (0.50) | BRD4HPGDSMAPK14MEN1ALPL | |
| SCHEMBL19174810 | 0.78 | KMT2A (0.55) | BRD4HPGDSLMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL736448 | 0.77 | POLB (0.50) | LMNAALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL2473674 | 0.77 | MEN1 (0.65) | MAPK14ALDH1A1MEN1ALPLKMT2A | |
| SCHEMBL736393 | 0.76 | SIRT6 (0.52) | BRD4LRRK2LMNAALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138373-B2 | Process for the manufacture of dihydropteridinones | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-03-20 | — | — | US | disclosed |
| US-20100249458-A1 | Process for the manufacture of dihydropteridinones | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-09-30 | — | — | US | disclosed |
| US-20080177066-A1 | Process for the manufacture of dihydropteridinones | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2008-07-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100249458-A1 | Process for the manufacture of dihydropteridinones | QDPR, DHPS, DHODH | BRD4 4869/4885HPGDS 66/4885LRRK2 1798/4885 |
| US-20080177066-A1 | Process for the manufacture of dihydropteridinones | QDPR, DHPS, DHODH | BRD4 4869/4885HPGDS 66/4885LRRK2 1798/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.