Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 4/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ADH5 | P11766 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MITF | O75030 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.37 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7526498 | 0.86 | CYP3A4 (0.42) | HTTCYP11B1CYP11B2CYP3A4BAZ2B | |
| SCHEMBL27814145 | 0.79 | HTT (0.52) | HTTCYP11B1CYP11B2CYP3A4BAZ2B | |
| SCHEMBL7524516 | 0.77 | MAPT (0.44) | HTTMAPTLMNAALDH1A1KDM4E | |
| SCHEMBL2085331 | 0.76 | KDM4E (0.51) | MAPTLMNAALDH1A1KDM4EMEN1 | |
| SCHEMBL14564357 | 0.76 | ICMT (0.47) | HTTMAPTLMNAALDH1A1KDM4E | |
| SCHEMBL5447791 | 0.74 | KDM4E (0.44) | MAPTLMNAALDH1A1KDM4EMEN1 | |
| SCHEMBL28836368 | 0.74 | MEN1 (0.50) | MAPTLMNAALDH1A1KDM4EMEN1 | |
| SCHEMBL7593302 | 0.74 | CYP3A4 (0.44) | HTTCYP11B1CYP11B2CYP3A4BAZ2B | |
| SCHEMBL7591435 | 0.74 | MAPT (0.49) | HTTMAPTLMNAALDH1A1KDM4E | |
| SCHEMBL31498840 | 0.71 | KDM4E (0.65) | MAPTLMNAALDH1A1KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1242409-A2 | SUBSTITUTED BISINDOLYLMALEIMIDES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-09-25 | — | — | EP | disclosed |
| US-6281356-B1 | ANTICANRCER AGENTS | HOFFMANN-LA ROCHE INC. | 2001-08-28 | — | — | US | disclosed |
| WO-2001046178-A2 | SUBSTITUIERTE BISINDOLYMALEIMIDE | F. HOFFMANN-LA ROCHE AG (CH) | 2001-06-28 | — | — | WO | disclosed |