Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.44 |
| ▸ | ADH5 | P11766 | 6/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | DHODH | Q02127 | 1/20 | 0.41 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.39 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.39 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.39 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MITF | O75030 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7526498 | 0.76 | CYP3A4 (0.42) | CYP3A4BAZ2BADH5HTTENPP2 | |
| SCHEMBL7592572 | 0.74 | HTT (0.46) | CYP3A4BAZ2BADH5HTTTBXAS1 | |
| SCHEMBL7525730 | 0.72 | KMT2A (0.44) | ENPP2MAPTLMNAKDM4EMEN1 | |
| SCHEMBL7522675 | 0.72 | ALDH1A1 (0.44) | CYP19A1LMNAMEN1ALDH1A1KMT2A | |
| SCHEMBL4002802 | 0.72 | SERPINE1 (0.47) | HTTIDO1LMNAKDM4EALDH1A1 | |
| SCHEMBL7591001 | 0.72 | PRKDC (0.47) | MAPTLMNAKDM4EMEN1ALDH1A1 | |
| SCHEMBL7526324 | 0.70 | ALDH1A1 (0.55) | KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL7535287 | 0.69 | IMPDH2 (0.41) | MAPTMEN1ALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL7521529 | 0.69 | HTT (0.44) | HTTTBXAS1KDM4EALDH1A1 | |
| SCHEMBL7531023 | 0.68 | CDK2 (0.62) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1242409-A2 | SUBSTITUTED BISINDOLYLMALEIMIDES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-09-25 | — | — | EP | disclosed |
| US-6281356-B1 | ANTICANRCER AGENTS | HOFFMANN-LA ROCHE INC. | 2001-08-28 | — | — | US | disclosed |
| WO-2001046178-A2 | SUBSTITUIERTE BISINDOLYMALEIMIDE | F. HOFFMANN-LA ROCHE AG (CH) | 2001-06-28 | — | — | WO | disclosed |