Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.42 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.41 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | ADH5 | P11766 | 4/20 | 0.39 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.38 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.38 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.37 |
| ▸ | ICMT | O60725 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | MITF | O75030 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7592572 | 0.86 | HTT (0.46) | CYP3A4BAZ2BPRMT5WDR77MAPT | |
| SCHEMBL7593302 | 0.76 | CYP3A4 (0.44) | CYP3A4BAZ2BMAPTHTTADH5 | |
| SCHEMBL7528351 | 0.76 | MAPT (0.46) | MAPTHTTLMNAICMTMEN1 | |
| SCHEMBL7593340 | 0.73 | MAPT (0.46) | CYP3A4BAZ2BMAPTHTTLMNA | |
| SCHEMBL20536593 | 0.70 | ADH5 (0.49) | CYP3A4BAZ2BMAPTHTTADH5 | |
| SCHEMBL30772970 | 0.70 | ADH5 (0.49) | CYP3A4BAZ2BMAPTHTTADH5 | |
| SCHEMBL30958421 | 0.70 | ICMT (0.62) | MAPTLMNAICMTKDM4EMEN1 | |
| SCHEMBL588980 | 0.70 | ICMT (0.62) | MAPTLMNAICMTKDM4EMEN1 | |
| SCHEMBL15782793 | 0.70 | GLS (0.56) | CYP3A4BAZ2BTBXAS1CYP11B1CYP11B2 | |
| SCHEMBL8444605 | 0.69 | CDK2 (0.50) | MAPTICMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1242409-A2 | SUBSTITUTED BISINDOLYLMALEIMIDES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-09-25 | — | — | EP | disclosed |
| US-6281356-B1 | ANTICANRCER AGENTS | HOFFMANN-LA ROCHE INC. | 2001-08-28 | — | — | US | disclosed |
| WO-2001046178-A2 | SUBSTITUIERTE BISINDOLYMALEIMIDE | F. HOFFMANN-LA ROCHE AG (CH) | 2001-06-28 | — | — | WO | disclosed |