Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.67 |
| ▸ | LMNA | P02545 | 2/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.60 |
| ▸ | MAPT | P10636 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | NPC1 | O15118 | 6/20 | 0.57 |
| ▸ | RAB9A | P51151 | 6/20 | 0.57 |
| ▸ | THRB | P10828 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11898237 | 0.81 | LMNA (0.64) | TP53LMNASMN1; SMN2MAPTKMT2A | |
| SCHEMBL27915823 | 0.78 | LMNA (0.77) | TP53LMNASMN1; SMN2MAPTKMT2A | |
| SCHEMBL26597943 | 0.77 | TP53 (0.52) | TP53LMNASMN1; SMN2MAPTKMT2A | |
| SCHEMBL28806937 | 0.76 | TP53 (0.57) | TP53LMNASMN1; SMN2MAPTKMT2A | |
| SCHEMBL28809095 | 0.75 | TP53 (0.55) | TP53LMNASMN1; SMN2MAPTKMT2A | |
| SCHEMBL5622343 | 0.71 | VNN1 (0.59) | MAPTKMT2AMEN1NPC1RAB9A | |
| SCHEMBL16940824 | 0.71 | TP53 (0.50) | TP53LMNASMN1; SMN2MAPTKMT2A | |
| SCHEMBL31500073 | 0.71 | LCK (0.61) | TP53LMNASMN1; SMN2MAPTKMT2A | |
| SCHEMBL2312890 | 0.69 | CXCR4 (0.74) | TP53MAPTKMT2ANPC1RAB9A | |
| SCHEMBL30102083 | 0.69 | CXCR4 (0.74) | TP53MAPTKMT2ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1206265-A4 | SRC KINASE INHIBITOR COMPOUNDS | MERCK & CO INC (US) | 2002-08-07 | — | — | EP | disclosed |
| EP-1206265-A1 | SRC KINASE INHIBITOR COMPOUNDS | Merck & Co., Inc. (US) | 2002-05-22 | — | — | EP | disclosed |
| WO-2001000213-A1 | SRC KINASE INHIBITOR COMPOUNDS | MERCK & CO., INC. (US) | 2001-01-04 | — | — | WO | disclosed |