Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 2/20 | 0.43 |
| ▸ | IDO1 | P14902 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | MMP12 | P39900 | 3/20 | 0.38 |
| ▸ | MMP1 | P03956 | 2/20 | 0.38 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.37 |
| ▸ | PTPN6 | P29350 | 3/20 | 0.37 |
| ▸ | PTPN11 | Q06124 | 3/20 | 0.37 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 1/20 | 0.35 |
| ▸ | MGLL | Q99685 | 1/20 | 0.35 |
| ▸ | KDM4A | O75164 | 1/20 | 0.35 |
| ▸ | KDM5A | P29375 | 1/20 | 0.35 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11229326 | 0.71 | IDO1 (0.62) | IDO1GPR84ABCB11SLC6A4 | |
| SCHEMBL4403101 | 0.70 | ALOX15 (0.54) | MEN1NPC1RAB9AKMT2AHRH4 | |
| SCHEMBL11965473 | 0.70 | CYP1A2 (0.45) | MEN1NPC1RAB9AKMT2AHRH4 | |
| SCHEMBL7593305 | 0.68 | KDM4A (0.44) | S1PR1IDO1PTPN1PTPN6PTPN11 | |
| SCHEMBL7135340 | 0.68 | ABCB11 (0.60) | KMT2AABCB11 | |
| SCHEMBL13593173 | 0.67 | HRH4 (0.55) | IDO1HRH4 | |
| SCHEMBL1504255 | 0.66 | HRH4 (0.57) | IDO1HRH4 | |
| SCHEMBL7087122 | 0.65 | ABCB11 (0.78) | ABCB11 | |
| SCHEMBL932921 | 0.64 | IDO1 (0.62) | IDO1GPR84ABCB11SLC6A4 | |
| SCHEMBL28785033 | 0.64 | IDO1 (0.52) | IDO1MEN1KMT2AGPR84 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1252142-A1 | INDOLE DERIVATIVES AS MCP-1 RECEPTOR ANTAGONISTS | AstraZeneca AB (SE) | 2002-10-30 | — | — | EP | disclosed |
| WO-2001051466-A1 | INDOLE DERIVATIVES AS MCP-1 RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2001-07-19 | — | — | WO | disclosed |